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Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials

Svensson, Fredric and Manivel, Vivek Anand and Seisenbaeva, Gulaim and Kessler, Vadim and Nilsson, Bo and Ekdahl, Kristina N. and Fromell, Karin (2021). Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials. Nanomaterials. 11 , 1100
[Research article]

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In order to develop a new type of improved wound dressing, we combined the wound healing properties of nanotitania with the advantageous dressing properties of nanocellulose to create three different hybrid materials. The hemocompatibility of the synthesized hybrid materials was evaluated in an in vitro human whole blood model. To our knowledge, this is the first study of the molecular interaction between hybrid nanotitania and blood proteins. Two of the hybrid materials prepared with 3 nm colloidal titania and 10 nm hydrothermally synthesized titania induced strong coagulation and platelet activation but negligible complement activation. Hence, they have great potential as a new dressing for promoting wound healing. Unlike the other two, the third hybrid material using molecular ammonium oxo-lactato titanate as a titania source inhibited platelet consumption, TAT generation, and complement activation, apparently via lowered pH at the surface interface. It is therefore suitable for applications where a passivating surface is desired, such as drug delivery systems and extracorporeal circuits. This opens the possibility for a tailored blood response through the surface functionalization of titania.

Authors/Creators:Svensson, Fredric and Manivel, Vivek Anand and Seisenbaeva, Gulaim and Kessler, Vadim and Nilsson, Bo and Ekdahl, Kristina N. and Fromell, Karin
Title:Hemocompatibility of Nanotitania-Nanocellulose Hybrid Materials
Series Name/Journal:Nanomaterials
Year of publishing :2021
Article number:1100
Number of Pages:13
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 2 Engineering and Technology > 210 Nano Technology > Nano Technology
Keywords:nanocellulose, titania, coagulation, platelets, complement system, contact system
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Additional ID:
Type of IDID
Web of Science (WoS)000657022100001
ID Code:24512
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:11 Jun 2021 08:03
Metadata Last Modified:16 May 2022 14:58

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