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Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos)

Pedrelli, Matteo and Parini, Paolo and Kindberg, Jonas and Arnemo, Jon and Bjorkhem, Ingemar and Aasa, Ulrika and Westerstahl, Maria and Walentinsson, Anna and Pavanello, Chiara and Turri, Marta and Calabresi, Laura and Oorni, Katariina and Camejo, German and Frobert, Ole and Hurt-Camejo, Eva (2021). Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos). Journal of Lipid Research. 62 , 100065
[Research article]

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Abstract

Plasma cholesterol and triglyceride (TG) levels are twice as high in hibernating brown bears (Ursus arctos) than healthy humans. Yet, bears display no signs of early stage atherosclerosis development when adult. To explore this apparent paradox, we analyzed plasma lipoproteins from the same 10 bears in winter (hibernation) and summer using size exclusion chromatography, ultracentrifugation, and electrophoresis. LDL binding to arterial proteoglycans (PGs) and plasma cholesterol efflux capacity (CEC) were also evaluated. The data collected and analyzed from bears were also compared with those from healthy humans. In bears, the cholesterol ester, unesterified cholesterol, TG, and phospholipid contents of VLDL and LDL were higher in winter than in summer. The percentage lipid composition of LDL differed between bears and humans but did not change seasonally in bears. Bear LDL was larger, richer in TGs, showed prebeta electrophoretic mobility, and had 5-10 times lower binding to arterial PGs than human LDL. Finally, plasma CEC was higher in bears than in humans, especially the HDL fraction when mediated by ABCA1. These results suggest that in brown bears the absence of early atherogenesis is likely associated with a lower affinity of LDL for arterial PGs and an elevated CEC of bear plasma.

Authors/Creators:Pedrelli, Matteo and Parini, Paolo and Kindberg, Jonas and Arnemo, Jon and Bjorkhem, Ingemar and Aasa, Ulrika and Westerstahl, Maria and Walentinsson, Anna and Pavanello, Chiara and Turri, Marta and Calabresi, Laura and Oorni, Katariina and Camejo, German and Frobert, Ole and Hurt-Camejo, Eva
Title:Vasculoprotective properties of plasma lipoproteins from brown bears (Ursus arctos)
Series Name/Journal:Journal of Lipid Research
Year of publishing :2021
Volume:62
Article number:100065
Number of Pages:12
Publisher:ELSEVIER
ISSN:0022-2275
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Ursus arctos, hibernation, lipids, apoB, lipoproteins, proteoglycans, cholesterol efflux, atherosclerosis, triglycerides, LDL
URN:NBN:urn:nbn:se:slu:epsilon-p-112163
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112163
Additional ID:
Type of IDID
DOI10.1016/j.jlr.2021.100065
Web of Science (WoS)000651435700001
ID Code:24522
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:11 Jun 2021 14:23
Metadata Last Modified:11 Jun 2021 14:31

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