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Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits

Strandberg, Erling and Friedrich, Juliane and Talenti, Andrea and Arvelius, Per and Haskell, Marie J. and Wiener, Pamela (2020). Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits. Advanced Genetics. 2 , e10024
[Research article]

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Abstract

Strong selection has resulted in substantial morphological and behavioral diversity across modern dog breeds, which makes dogs interesting model animals to study the underlying genetic architecture of these traits. However, results from between-breed analyses may confound selection signatures for behavior and morphological features that were coselected during breed development. In this study, we assess population genetic differences in a unique resource of dogs of the same breed but with systematic behavioral selection in only one population. We exploit these different breeding backgrounds to identify signatures of recent selection. Selection signatures within populations were found on chromosomes 4 and 19, with the strongest signals in behavior-related genes. Regions showing strong signals of divergent selection were located on chromosomes 1, 24, and 32, and include candidate genes for both physical features and behavior. Some of the selection signatures appear to be driven by loci associated with coat color (Chr 24; ASIP) and length (Chr 32; FGF5), while others showed evidence of association with behavior. Our findings suggest that signatures of selection within dog breeds have been driven by selection for morphology and behavior. Furthermore, we demonstrate that combining selection scans with association analyses is effective for dissecting the traits under selection.

Authors/Creators:Strandberg, Erling and Friedrich, Juliane and Talenti, Andrea and Arvelius, Per and Haskell, Marie J. and Wiener, Pamela
Title:Unravelling selection signatures in a single dog breed suggests recent selection for morphological and behavioral traits
Series Name/Journal:Advanced Genetics
Year of publishing :2020
Volume:2
Article number:e10024
Number of Pages:14
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402)
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:association analysis, coat color, dog behavior, German Shepherd dog, positive selection
URN:NBN:urn:nbn:se:slu:epsilon-p-112284
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112284
Additional ID:
Type of IDID
DOI10.1002/ggn2.10024
ID Code:24528
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:14 Jun 2021 10:43
Metadata Last Modified:14 Jun 2021 10:51

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