Home About Browse Search
Svenska


The crest phenotype in domestic chicken is caused by a 197 bp duplication in the intron of HOXC10

Li, Jingyi and Lee, Mi-Ok and Davis, Brian W. and Wu, Ping and Li, Shu-Man Hsieh and Chuong, Cheng-Ming and Andersson, Leif (2021). The crest phenotype in domestic chicken is caused by a 197 bp duplication in the intron of HOXC10. G3. 11 , jkaa048
[Research article]

[img] PDF
886kB

Abstract

The Crest mutation in chicken shows incomplete dominance and causes a spectacular phenotype in which the small feathers normally present on the head are replaced by much larger feathers normally present only in dorsal skin. Using whole-genome sequencing, we show that the crest phenotype is caused by a 197 bp duplication of an evolutionarily conserved sequence located in the intron of HOXC10 on chromosome 33. A diagnostic test showed that the duplication was present in all 54 crested chickens representing eight breeds and absent from all 433 non-crested chickens representing 214 populations. The mutation causes ectopic expression of at least five closely linked HOXC genes, including HOXC10, in cranial skin of crested chickens. The result is consistent with the interpretation that the crest feathers are caused by an altered body region identity. The upregulated HOXC gene expression is expanded to skull tissue of Polish chickens showing a large crest often associated with cerebral hernia, but not in Silkie chickens characterized by a small crest, both homozygous for the duplication. Thus, the 197 bp duplication is required for the development of a large crest and susceptibility to cerebral hernia because only crested chicken show this malformation. However, this mutation is not sufficient to cause herniation because this malformation is not present in breeds with a small crest, like Silkie chickens.

Authors/Creators:Li, Jingyi and Lee, Mi-Ok and Davis, Brian W. and Wu, Ping and Li, Shu-Man Hsieh and Chuong, Cheng-Ming and Andersson, Leif
Title:The crest phenotype in domestic chicken is caused by a 197 bp duplication in the intron of HOXC10
Series Name/Journal:G3
Year of publishing :2021
Volume:11
Article number:jkaa048
Number of Pages:10
Publisher:OXFORD UNIV PRESS INC
ISSN:2160-1836
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:crest, skin regional specificity, cerebral hernia, IBD mapping, HOXC gene cluster
URN:NBN:urn:nbn:se:slu:epsilon-p-112273
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112273
Additional ID:
Type of IDID
DOI10.1093/g3journal/jkaa048
Web of Science (WoS)000651850600012
ID Code:24555
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:17 Jun 2021 10:03
Metadata Last Modified:17 Jun 2021 10:11

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits