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Water temperature affects the biotransformation and accumulation of a psychoactive pharmaceutical and its biologically active metabolite in aquatic organisms

Cerveny, Daniel and Fick, J. and Klaminder, Jonatan and McCallum, Erin and Bertram, Michael and Castillo, N. A. and Brodin, Tomas (2021). Water temperature affects the biotransformation and accumulation of a psychoactive pharmaceutical and its biologically active metabolite in aquatic organisms. Environment International. 155 , 106705
[Research article]

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Abstract

Pharmaceutically active compounds (PhACs) have been shown to accumulate in aquatic and riparian food-webs. Yet, our understanding of how temperature, a key environmental factor in nature, affects uptake, biotransformation, and the subsequent accumulation of PhACs in aquatic organisms is limited. In this study, we tested to what extent bioconcentration of an anxiolytic drugs (temazepam and oxazepam) is affected by two temperature regimes (10 and 20 °C) and how the temperature affects the temazepam biotransformation and subsequent accumulation of its metabolite (oxazepam) in aquatic organisms. We used European perch (Perca fluviatilis) and dragonfly larvae (Sympetrum sp.), which represent predator and prey species of high ecological relevance in food chains of boreal and temperate aquatic ecosystems. Experimental organisms were exposed to target pharmaceuticals at a range of concentrations (0.2–6 µg L−1) to study concentration dependent differences in bioconcentration and biotransformation. We found that the bioconcentration of temazepam in perch was significantly reduced at higher temperatures. Also, temperature had a strong effect on temazepam biotransformation in the fish, with the production and subsequent accumulation of its metabolite (oxazepam) being two-fold higher at 20 °C compared to 10 °C. In contrast, we found no temperature dependency for temazepam bioconcentration in dragonfly larvae and no detectable biotransformation of the parent compound that would result in measurable concentrations of oxazepam in this organism. Our results highlight that while organisms may share the same aquatic ecosystem, their exposure to PhACs may change differently across temperature gradients in the environment.

Authors/Creators:Cerveny, Daniel and Fick, J. and Klaminder, Jonatan and McCallum, Erin and Bertram, Michael and Castillo, N. A. and Brodin, Tomas
Title:Water temperature affects the biotransformation and accumulation of a psychoactive pharmaceutical and its biologically active metabolite in aquatic organisms
Series Name/Journal:Environment International
Year of publishing :2021
Volume:155
Article number:106705
Number of Pages:8
ISSN:0160-4120
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:Aquatic invertebrate, Benzodiazepine, Drug, Fish, Dragonfly, Temazepam
URN:NBN:urn:nbn:se:slu:epsilon-p-112360
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112360
Additional ID:
Type of IDID
DOI10.1016/j.envint.2021.106705
ID Code:24571
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:21 Jun 2021 10:43
Metadata Last Modified:21 Jun 2021 10:51

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