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Epidemiology and eradication of bovine viral diarrhoea virus infections

studies on transmission and prenatal diagnosis of persistent infection

Lindberg, Ann (2002). Epidemiology and eradication of bovine viral diarrhoea virus infections. Diss. (sammanfattning/summary) Uppsala : Sveriges lantbruksuniv., Acta Universitatis agriculturae Sueciae. Veterinaria, 1401-6257 ; 132
ISBN 91-576-6384-X
[Doctoral thesis]

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Abstract

This thesis describes the principles for eradication of bovine viral diarrhoea (BVDV) from cattle populations without the use of vaccines, as they have been applied in the Scandinavian countries since 1993-94. It also presents five studies concerning transmission of BVDV and prenatal diagnosis of persistent BVDV infection. The studies relate to large-scale eradication by addressing issues of importance for elimination of virus in infected herds, for management of recently infected herds and for prevention of BVDV transmission through livestock trade. Transmission of primary type I BVDV infections in the absence of persistently infected (PI) animals was studied. Calves undergoing acute infection with BVDV were brought in contact with healthy, non-immune calves. Also, calves inoculated with BVDV were housed with non-immune calves, while they all underwent a concurrent infection with bovine coronavirus. In both studies, none of the in-contact calves seroconverted. This suggests that primary infections are of low infectivity and that virus circulation will cease after PI animals have been removed. The ability to identify dams pregnant with PI foetuses (PI carriers) before parturition was investigated. Using an indirect antibody ELISA on samples taken in late gestation, it was possible to discriminate PI carriers from other antibody positive pregnant cows in herds with ongoing infection. It was also possible to detect viral antigen in foetal fluids from PI carriers by an RT-PCR assay and by virus isolation (VI). RT-PCR was superior to VI in this respect. Serology can be used to prevent PI carriers from being traded, and both methods can be used to delimit outbreaks of BVDV in infected herds. The infectivity associated with foetal fluids and uterine lochia was tested by exposing non-immune calves to such samples. It was shown that foetal fluids can be infectious, but to a low extent. Uterine lochias are not likely to be infectious. Also, the infectivity associated with dams delivering PI calves, and their calving environment, was studied by putting susceptible calves in repeated contact with such dams after removal of the PI offspring. It was shown that rapid removal of newborn PI calves does not prevent further spread of BVDV infection to susceptible animals.

Authors/Creators:Lindberg, Ann
Title:Epidemiology and eradication of bovine viral diarrhoea virus infections
Subtitle:studies on transmission and prenatal diagnosis of persistent infection
Year of publishing :April 2002
Volume:132
Number of Pages:56
Papers/manuscripts:
NumberReferences
ALLI. Niskanen, R., Lindberg, A., Larsson, B. and Alenius, S. Lack of virus transmission from bovine viral diarrhoea virus infected calves to susceptible peers. Acta Veterinaria Scandinavica (2000) 41: 93-99. II. Niskanen, R., Lindberg, A. and Tråvén, M. Failure to spread bovine virus diarrhoea virus infection from primarily infected calves despite concurrent infection with bovine coronavirus. Veterinary Journal (2002) 163:251-259. III. Lindberg, A., Groenendaal, H., Alenius, S. and Emanuelson, U. Validation of a test for dams carrying foetuses persistently infected with bovine viral diarrhoea virus based on determination of antibody levels in late pregnancy. Preventive Veterinary Medicine (2001) 51: 199-214. IV. Lindberg, A., Niskanen, R., Gustafsson, H., Bengtsson, B., Baule, C., Belák, S. and Alenius, S. Prenatal diagnosis of persistent bovine viral diarrhoea virus (BVDV) infection by detection of viral RNA in foetal fluids. (2002) Veterinary Journal. 164: 151-155. V. Lindberg, A., Stokstad, M., Løken, T., Alenius, S. and Niskanen, R. Indirect transmission of bovine viral diarrhoea virus at calving and during the postparturient period. (Accepted for publication, Veterinary Record). VI. Lindberg, A. and Alenius, S. Principles for eradication of bovine viral diarrhoea virus (BVDV) infections in cattle populations. Veterinary Microbiology (1999) 64: 197-222.
Place of Publication:Uppsala
ISBN for printed version:91-576-6384-X
ISSN:1401-6257
Language:English
Publication Type:Doctoral thesis
Full Text Status:Public
Agris subject categories.:L Animal production > L73 Animal diseases
Subjects:Not in use, please see Agris categories
Agrovoc terms:dairy cattle, beef cattle, calves, mothers, bovine diarrhoea pestivirus, infection, risk, epidemiology, foetus, perinatal period, diagnosis, disease control, statistical methods, sweden
Keywords:cattle, pestivirus, BVDV, experimental study, test validation, foetal fluid, indirect transmission, control, risk factor
URN:NBN:urn:nbn:se:slu:epsilon-336
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-336
ID Code:246
Department:(VH) > Institutionen för idisslarmedicin och epidemiologi ( 970401-040630)
Deposited By: Ann Lindberg
Deposited On:22 Apr 2003 00:00
Metadata Last Modified:02 Dec 2014 10:03

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