Ahmad, Freed and Debes, Paul V. and Nousiainen, Ilkka and Kahar, Siim and Pukk, Lilian and Gross, Riho and Ozerov, Mikhail and Vasemägi, Anti
(2021).
The strength and form of natural selection on transcript abundance in the wild.
Molecular Ecology. 30
, 2724–2737
[Research article]
![]() |
PDF
1MB |
Abstract
Gene transcription variation is known to contribute to disease susceptibility and adaptation, but we currently know very little about how contemporary natural selection shapes transcript abundance. Here, we propose a novel analytical framework to quantify the strength and form of ongoing natural selection at the transcriptome level in a wild vertebrate. We estimated selection on transcript abundance in a cohort of a wild salmonid fish (Salmo trutta) affected by an extracellular myxozoan parasite (Tetracapsuloides bryosalmonae) through mark-recapture field sampling and the integration of RNA-sequencing with classical regression-based selection analysis. We show, based on fin transcriptomes of the host, that infection by the parasite and subsequent host survival is linked to upregulation of mitotic cell cycle process. We also detect a widespread signal of disruptive selection on transcripts linked to host immune defence, host-pathogen interactions, cellular repair and maintenance. Our results provide insights into how selection can be measured at the transcriptome level to dissect the molecular mechanisms of contemporary evolution driven by climate change and emerging anthropogenic threats. We anticipate that the approach described here will enable critical information on the molecular processes and targets of natural selection to be obtained in real time.
Authors/Creators: | Ahmad, Freed and Debes, Paul V. and Nousiainen, Ilkka and Kahar, Siim and Pukk, Lilian and Gross, Riho and Ozerov, Mikhail and Vasemägi, Anti | ||||||
---|---|---|---|---|---|---|---|
Title: | The strength and form of natural selection on transcript abundance in the wild | ||||||
Series Name/Journal: | Molecular Ecology | ||||||
Year of publishing : | 2021 | ||||||
Volume: | 30 | ||||||
Page range: | 2724–2737 | ||||||
Number of Pages: | 14 | ||||||
ISSN: | 0962-1083 | ||||||
Language: | English | ||||||
Publication Type: | Research article | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Bioinformatics and Systems Biology (methods development to be 10203) (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402) | ||||||
Keywords: | climate change, contemporary natural selection, gene expression, host–parasite relationships, selection differential and gradient | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-108958 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108958 | ||||||
Additional ID: |
| ||||||
ID Code: | 24766 | ||||||
Faculty: | NJ - Fakulteten för naturresurser och jordbruksvetenskap | ||||||
Department: | (NL, NJ) > Department of Aquatic Resources | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 30 Jun 2021 12:25 | ||||||
Metadata Last Modified: | 30 Jun 2021 12:31 |
Repository Staff Only: item control page