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The strength and form of natural selection on transcript abundance in the wild

Ahmad, Freed and Debes, Paul V. and Nousiainen, Ilkka and Kahar, Siim and Pukk, Lilian and Gross, Riho and Ozerov, Mikhail and Vasemägi, Anti (2021). The strength and form of natural selection on transcript abundance in the wild. Molecular Ecology. 30 , 2724–2737
[Research article]

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Abstract

Gene transcription variation is known to contribute to disease susceptibility and adaptation, but we currently know very little about how contemporary natural selection shapes transcript abundance. Here, we propose a novel analytical framework to quantify the strength and form of ongoing natural selection at the transcriptome level in a wild vertebrate. We estimated selection on transcript abundance in a cohort of a wild salmonid fish (Salmo trutta) affected by an extracellular myxozoan parasite (Tetracapsuloides bryosalmonae) through mark-recapture field sampling and the integration of RNA-sequencing with classical regression-based selection analysis. We show, based on fin transcriptomes of the host, that infection by the parasite and subsequent host survival is linked to upregulation of mitotic cell cycle process. We also detect a widespread signal of disruptive selection on transcripts linked to host immune defence, host-pathogen interactions, cellular repair and maintenance. Our results provide insights into how selection can be measured at the transcriptome level to dissect the molecular mechanisms of contemporary evolution driven by climate change and emerging anthropogenic threats. We anticipate that the approach described here will enable critical information on the molecular processes and targets of natural selection to be obtained in real time.

Authors/Creators:Ahmad, Freed and Debes, Paul V. and Nousiainen, Ilkka and Kahar, Siim and Pukk, Lilian and Gross, Riho and Ozerov, Mikhail and Vasemägi, Anti
Title:The strength and form of natural selection on transcript abundance in the wild
Series Name/Journal:Molecular Ecology
Year of publishing :2021
Volume:30
Page range:2724–2737
Number of Pages:14
ISSN:0962-1083
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Bioinformatics and Systems Biology (methods development to be 10203)
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402)
Keywords:climate change, contemporary natural selection, gene expression, host–parasite relationships, selection differential and gradient
URN:NBN:urn:nbn:se:slu:epsilon-p-108958
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108958
Additional ID:
Type of IDID
DOI10.1111/mec.15743
Web of Science (WoS)000596112400001
ID Code:24766
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Aquatic Resources
Deposited By: SLUpub Connector
Deposited On:30 Jun 2021 12:25
Metadata Last Modified:30 Jun 2021 12:31

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