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Platelet function in the Scandinavian brown bear (Ursus arctos) compared to man

Fröbert, Ole and Christensen, Kjeld and Fahlman, Åsa and Brunberg, Sven and Josefsson, Johan and Särndahl, Eva and Swenson, Jon E. and Arnemo, Jon (2010). Platelet function in the Scandinavian brown bear (Ursus arctos) compared to man. Thrombosis Journal. 8 , 11 , 1-5
[Research article]

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Abstract

BACKGROUND: Information on hemostasis and platelet function in brown bear (Ursus arctos) is of importance for understanding the physiological, protective changes during hibernation. OBJECTIVE: The study objective was to document platelet activity values in brown bears shortly after leaving the den and compare them to platelet function in healthy humans. METHODS: Blood was drawn from immobilized wild brown bears 7-10 days after leaving the den in mid April. Blood samples from healthy human adults before and after clopidogrel and acetylsalicylic acid administration served as control. We analyzed blood samples by standard blood testing and platelet aggregation was quantified after stimulation with various agonists using multiple electrode aggregometry within 3 hours of sampling. RESULTS: Blood samples were collected from 6 bears (3 females) between 1 and 16 years old and from 10 healthy humans. Results of adenosine diphosphate, aspirin, and thrombin receptor activating peptide tests in bears were all half or less of those in humans. Platelet and white blood cell counts did not differ between species but brown bears had more and smaller red blood cells compared with humans. CONCLUSION: Using three different tests, we conclude that platelet function is lower in brown bears compared to humans. Our findings represent the first descriptive study on platelet function in brown bears and may contribute to explain how bears can endure denning without obvious thrombus building. However, the possibility that our findings reflect test-dependent and not true biological variations in platelet reactivity needs further studies.

Authors/Creators:Fröbert, Ole and Christensen, Kjeld and Fahlman, Åsa and Brunberg, Sven and Josefsson, Johan and Särndahl, Eva and Swenson, Jon E. and Arnemo, Jon
Title:Platelet function in the Scandinavian brown bear (Ursus arctos) compared to man
Series Name/Journal:Thrombosis Journal
Year of publishing :2010
Volume:8
Article number:11
Number of Pages:5
ISSN:1477-9560
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 3.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science
URN:NBN:urn:nbn:se:slu:epsilon-p-32171
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-32171
Additional ID:
Type of IDID
DOI10.1186/1477-9560-8-11
ID Code:24805
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
S - Faculty of Forest Sciences
Department:(VH) > Dept. of Clinical Sciences
(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:06 Jul 2021 07:26
Metadata Last Modified:06 Jul 2021 07:31

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