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Concentrations of nine endogenous steroid hormones in 70-year-old men and women

Penell, Johanna and Kushnir, Mark M. and Lind, Lars and Bergquist, Jonatan and Bergquist, Jonas and Lind, P. Monica and Naessen, Tord (2021). Concentrations of nine endogenous steroid hormones in 70-year-old men and women. Endocrine Connections. 10 , 511-520
[Research article]

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Abstract

Objectives: Circulating concentrations of endogenous steroids have systemic implications on health in elderly. However, population-based age- and ethnicity-specific data are scarce. The aim was to report sex-specific plasma concentrations of endogenous sex and adrenal steroids in elderly Swedish Caucasians, to examine the impact of BMI and to present concentrations in apparently healthy subjects.Methods: A population-based observational study of 70-year olds, including 684 community-dwelling men and women enrolled in the PIVUS study, Sweden. Median plasma concentrations were determined using liquid chromatography-tandem mass spectrometry (LC-MS/MS) for pregnenolone, 17-hydroxypregnenolone, 17-hydroxyprogesterone, 11-deoxycortisol, DHEA, androstenedione, testosterone, estrone and estradiol.Results: Plasma concentrations were significantly higher in men (n = 452) than in women (n = 232) for estradiol: median 61.3 pmol/L (95% CI, 11.4, 142.7) vs 18.4 (4.0, 127.3), for estrone: 92.8 (33.3, 206) vs 71.6 (17.8, 209) pmol/L, and for testosterone 13.8 (5.7, 28.0) vs 0.7 (0.2, 2.0) nmol/L. Higher concentrations of estrone and estradiol were observed in obese than non-obese women. Compared to non-obese men, obese men had lower concentrations of testosterone and its precursors: 17-hydroxypregnenolone, 17-hydroxyprogesterone, androstenedione and DHEA. The subgroup of apparently healthy individuals had median values > 20% lower for estrone and estradiol in women but slightly higher for testosterone in both sexes.Conclusions: Concentrations of estradiol, estrone and testosterone were higher in 70-yearold men than in women. BMI associated positively to estradiol and estrone in women and negatively to testosterone in men. Apparently healthy women had lower median concentrations of estradiol and estrone and men had higher median testosterone compared to all individuals.

Authors/Creators:Penell, Johanna and Kushnir, Mark M. and Lind, Lars and Bergquist, Jonatan and Bergquist, Jonas and Lind, P. Monica and Naessen, Tord
Title:Concentrations of nine endogenous steroid hormones in 70-year-old men and women
Series Name/Journal:Endocrine Connections
Year of publishing :2021
Volume:10
Page range:511-520
Number of Pages:10
Publisher:BIOSCIENTIFICA LTD
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Public Health, Global Health, Social Medicine and Epidemiology
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Endocrinology and Diabetes
Keywords:endogenous, sex steroids, elderly, population-based, liquid chromatography-tandem mass spectrometry
URN:NBN:urn:nbn:se:slu:epsilon-p-112715
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112715
Additional ID:
Type of IDID
DOI10.1530/EC-21-0045
Web of Science (WoS)000661111700007
ID Code:24835
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:09 Jul 2021 15:25
Metadata Last Modified:09 Jul 2021 15:31

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