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Prevalence of Orthohantavirus-Reactive Antibodies in Humans and Peri-Domestic Rodents in Northern Ethiopia

Meheretu, Yonas and Granberg, Asa and Berhane, Gebregiorgis and Khalil, Hussein and Lwande, Olivia Wesula and Mitiku, Mengistu and Welegerima, Kiros and de Bellocq, Joelle Gouy and Bryja, Josef and Abreha, Hagos and Leirs, Herwig and Ecke, Frauke and Evander, Magnus (2021). Prevalence of Orthohantavirus-Reactive Antibodies in Humans and Peri-Domestic Rodents in Northern Ethiopia. Viruses. 13 , 1054
[Research article]

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Abstract

In 2012, Tigray orthohantavirus was discovered in Ethiopia, but its seasonal infection in small mammals, and whether it poses a risk to humans was unknown. The occurrence of small mammals, rodents and shrews, in human inhabitations in northern Ethiopia is affected by season and presence of stone bunds. We sampled small mammals in two seasons from low- and high-density stone bund fields adjacent to houses and community-protected semi-natural habitats in Atsbi and Hagere Selam, where Tigray orthohantavirus was first discovered. We collected blood samples from both small mammals and residents using filter paper. The presence of orthohantavirus-reactive antibodies in blood was then analyzed using immunofluorescence assay (human samples) and enzyme linked immunosorbent assays (small mammal samples) with Puumala orthohantavirus as antigen. Viral RNA was detected by RT-PCR using small mammal blood samples. Total orthohantavirus prevalence (antibodies or virus RNA) in the small mammals was 3.37%. The positive animals were three Stenocephalemys albipes rats (prevalence in this species = 13.04%). The low prevalence made it impossible to determine whether season and stone bunds were associated with orthohantavirus prevalence in the small mammals. In humans, we report the first detection of orthohantavirus-reactive IgG antibodies in Ethiopia (seroprevalence = 5.26%). S. albipes lives in close proximity to humans, likely increasing the risk of zoonotic transmission.

Authors/Creators:Meheretu, Yonas and Granberg, Asa and Berhane, Gebregiorgis and Khalil, Hussein and Lwande, Olivia Wesula and Mitiku, Mengistu and Welegerima, Kiros and de Bellocq, Joelle Gouy and Bryja, Josef and Abreha, Hagos and Leirs, Herwig and Ecke, Frauke and Evander, Magnus
Title:Prevalence of Orthohantavirus-Reactive Antibodies in Humans and Peri-Domestic Rodents in Northern Ethiopia
Series Name/Journal:Viruses
Year of publishing :2021
Volume:13
Article number:1054
Number of Pages:15
Publisher:MDPI
ISSN:1999-4915
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Microbiology in the medical area
Keywords:orthohantavirus, rodents, rural community, risk factors, Ethiopia
URN:NBN:urn:nbn:se:slu:epsilon-p-112777
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112777
Additional ID:
Type of IDID
DOI10.3390/v13061054
Web of Science (WoS)000667380700001
ID Code:24858
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:14 Jul 2021 10:36
Metadata Last Modified:14 Jul 2021 10:41

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