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Genetic variation in recombination rate in the pig

Johnsson, Martin and Whalen, Andrew and Ros-Freixedes, Roger and Gorjanc, Gregor and Chen, Ching-Yi and Herring, William O. and De Koning, Dirk-Jan and Hickey, John M. (2021). Genetic variation in recombination rate in the pig. Genetics Selection Evolution. 53 , 54
[Research article]

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Abstract

Background Meiotic recombination results in the exchange of genetic material between homologous chromosomes. Recombination rate varies between different parts of the genome, between individuals, and is influenced by genetics. In this paper, we assessed the genetic variation in recombination rate along the genome and between individuals in the pig using multilocus iterative peeling on 150,000 individuals across nine genotyped pedigrees. We used these data to estimate the heritability of recombination and perform a genome-wide association study of recombination in the pig. Results Our results confirmed known features of the recombination landscape of the pig genome, including differences in genetic length of chromosomes and marked sex differences. The recombination landscape was repeatable between lines, but at the same time, there were differences in average autosome-wide recombination rate between lines. The heritability of autosome-wide recombination rate was low but not zero (on average 0.07 for females and 0.05 for males). We found six genomic regions that are associated with recombination rate, among which five harbour known candidate genes involved in recombination: RNF212, SHOC1, SYCP2, MSH4 and HFM1. Conclusions Our results on the variation in recombination rate in the pig genome agree with those reported for other vertebrates, with a low but nonzero heritability, and the identification of a major quantitative trait locus for recombination rate that is homologous to that detected in several other species. This work also highlights the utility of using large-scale livestock data to understand biological processes.

Authors/Creators:Johnsson, Martin and Whalen, Andrew and Ros-Freixedes, Roger and Gorjanc, Gregor and Chen, Ching-Yi and Herring, William O. and De Koning, Dirk-Jan and Hickey, John M.
Title:Genetic variation in recombination rate in the pig
Series Name/Journal:Genetics Selection Evolution
Year of publishing :2021
Volume:53
Article number:54
Number of Pages:19
ISSN:0999-193X
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 404 Agricultural Biotechnology > Genetics and Breeding
URN:NBN:urn:nbn:se:slu:epsilon-p-112805
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112805
Additional ID:
Type of IDID
DOI10.1101/2020.03.17.995969
Web of Science (WoS)000667059200002
ID Code:24876
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:12 Aug 2021 07:25
Metadata Last Modified:12 Aug 2021 07:31

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