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Risk factors for the delayed viral clearance in COVID-19 patients

Chen, Xiaoping and Hu, Wenjia and Yang, Miao and Ling, Jiaxin and Zhang, Yongxi and Deng, Liping and Li, Jinlin and Lundkvist, Ake and Lindahl, Johanna and Xiong, Yong (2021). Risk factors for the delayed viral clearance in COVID-19 patients. The journal of clinical hypertension. 23 , 1483-1489
[Research article]

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Abstract

Comorbidities are important for the disease outcome of COVID-19, however, which underlying diseases that contribute the most to aggravate the conditions of COVID-19 patients are still unclear. Viral clearance is the most important laboratory test for defining the recovery of COVID-19 infections. To better understand which underlying diseases that are risk factors for delaying the viral clearance, we retrospectively analyzed 161 COVID-19 clinical cases in the Zhongnan Hospital of Wuhan University, Wuhan, China between January 5 and March 13, 2020. The demographic, clinical and laboratory data, as well as patient treatment records were collected. Univariable and multivariable analysis were performed to explore the association between delayed viral clearance and other factors by using logistic regression. Survival analyses by Kaplan-Meier and Cox regression modeling were employed to identify factors negatively influencing the viral clearance negatively. We found that hypertension and intravenous immunoglobulin adversely affected the time of viral RNA shedding. Hypertension was the most important risk factor to delay the SARS-CoV-2 virus clearance, however, the use of Angiotensin-Converting Enzyme Inhibitors(ACEI)/Angiotensin Receptor Blockers(ARB) did not shorten the time for virus clearance in these hypertensive patients' virus clearance. We conclude that patients having hypertension and intravenous immunoglobulin may delay the viral clearance in COVID-19 patients.

Authors/Creators:Chen, Xiaoping and Hu, Wenjia and Yang, Miao and Ling, Jiaxin and Zhang, Yongxi and Deng, Liping and Li, Jinlin and Lundkvist, Ake and Lindahl, Johanna and Xiong, Yong
Title:Risk factors for the delayed viral clearance in COVID-19 patients
Series Name/Journal:The journal of clinical hypertension
Year of publishing :2021
Volume:23
Page range:1483-1489
Number of Pages:7
Publisher:WILEY
ISSN:1524-6175
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Infectious Medicine
Keywords:COVID-19, hypertension, risk factors, SARS-CoV-2, viral clearance
URN:NBN:urn:nbn:se:slu:epsilon-p-113024
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113024
Additional ID:
Type of IDID
DOI10.1111/jch.14308
Web of Science (WoS)000667913300001
ID Code:24995
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:24 Aug 2021 07:25
Metadata Last Modified:24 Aug 2021 07:31

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