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Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)

Krais, Annette M. and Essig, Julie Y. and Gren, Louise and Vogs, Carolina and Assarsson, Eva and Dierschke, Katrin and Nielsen, Jorn and Strandberg, Bo and Pagels, Joakim and Broberg, Karin and Lindh, Christian H. and Gudmundsson, Anders and Wierzbicka, Aneta (2021). Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO). International journal of environmental research and public health. 18 , 6492
[Research article]

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Abstract

Hydrogenated vegetable oil (HVO) is a renewable diesel fuel used to replace petroleum diesel. The organic compounds in HVO are poorly characterized; therefore, toxicological properties could be different from petroleum diesel exhaust. The aim of this study was to evaluate the exposure and effective biomarkers in 18 individuals after short-term (3 h) exposure to HVO exhaust and petroleum diesel exhaust fumes. Liquid chromatography tandem mass spectrometry was used to analyze urinary biomarkers. A proximity extension assay was used for the measurement of inflammatory proteins in plasma samples. Short-term (3 h) exposure to HVO exhaust (PM1 similar to 1 mu g/m(3) and similar to 90 mu g/m(3) for vehicles with and without exhaust aftertreatment systems, respectively) did not increase any exposure biomarker, whereas petroleum diesel exhaust (PM1 similar to 300 mu g/m(3)) increased urinary 4-MHA, a biomarker for p-xylene. HVO exhaust from the vehicle without exhaust aftertreatment system increased urinary 4-HNE-MA, a biomarker for lipid peroxidation, from 64 ng/mL urine (before exposure) to 141 ng/mL (24 h after exposure, p < 0.001). There was no differential expression of plasma inflammatory proteins between the HVO exhaust and control exposure group. In conclusion, short-term exposure to low concentrations of HVO exhaust did not increase urinary exposure biomarkers, but caused a slight increase in lipid peroxidation associated with the particle fraction.

Authors/Creators:Krais, Annette M. and Essig, Julie Y. and Gren, Louise and Vogs, Carolina and Assarsson, Eva and Dierschke, Katrin and Nielsen, Jorn and Strandberg, Bo and Pagels, Joakim and Broberg, Karin and Lindh, Christian H. and Gudmundsson, Anders and Wierzbicka, Aneta
Title:Biomarkers after Controlled Inhalation Exposure to Exhaust from Hydrogenated Vegetable Oil (HVO)
Series Name/Journal:International journal of environmental research and public health
Year of publishing :2021
Volume:18
Article number:6492
Number of Pages:15
Publisher:MDPI
ISSN:1661-7827
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Environmental Health and Occupational Health
Keywords:renewable diesel, HVO, exposure studies, biomarkers, aerosol, lipid peroxidation
URN:NBN:urn:nbn:se:slu:epsilon-p-112971
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112971
Additional ID:
Type of IDID
DOI10.3390/ijerph18126492
Web of Science (WoS)000665996400001
ID Code:25050
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:26 Aug 2021 11:25
Metadata Last Modified:26 Aug 2021 11:31

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