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Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice

Johanson, Silje Modahl and Ropstad, Erik and Ostby, Gunn Charlotte and Aleksandersen, Mona and Zamaratskaia, Galia and Boge, Gudrun Seeberg and Halsne, Ruth and Trangerud, Cathrine and Lyche, Jan Ludvig and Berntsen, Hanne Friis and Zimmer, Karin Elisabeth and Verhaegen, Steven (2021). Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice. PLoS ONE. 16 , e0252954
[Research article]

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Abstract

The ability of persistent organic pollutants (POPs) with endocrine disrupting properties to interfere with the developing reproductive system is of increasing concern. POPs are transferred from dams to offspring and the high sensitivity of neonates to endocrine disturbances may be caused by underdeveloped systems of metabolism and excretion. The present study aimed to characterize the effect of in utero and lactational exposure to a human relevant mixture of POPs on the female mammary gland, ovarian folliculogenesis and liver function in CD-1 offspring mice. Dams were exposed to the mixture through the diet at Control, Low or High doses (representing 0x, 5000x and 100 000x human estimated daily intake levels, respectively) from weaning and throughout mating, gestation, and lactation. Perinatally exposed female offspring exhibited altered mammary gland development and a suppressed ovarian follicle maturation. Increased hepatic cytochrome P450 enzymatic activities indirectly indicated activation of nuclear receptors and potential generation of reactive products. Hepatocellular hypertrophy was observed from weaning until 30 weeks of age and could potentially lead to hepatotoxicity. Further studies should investigate the effects of human relevant mixtures of POPs on several hormones combined with female reproductive ability and liver function.

Authors/Creators:Johanson, Silje Modahl and Ropstad, Erik and Ostby, Gunn Charlotte and Aleksandersen, Mona and Zamaratskaia, Galia and Boge, Gudrun Seeberg and Halsne, Ruth and Trangerud, Cathrine and Lyche, Jan Ludvig and Berntsen, Hanne Friis and Zimmer, Karin Elisabeth and Verhaegen, Steven
Title:Perinatal exposure to a human relevant mixture of persistent organic pollutants: Effects on mammary gland development, ovarian folliculogenesis and liver in CD-1 mice
Series Name/Journal:PLoS ONE
Year of publishing :2021
Volume:16
Article number:e0252954
Number of Pages:24
Publisher:PUBLIC LIBRARY SCIENCE
ISSN:1932-6203
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
URN:NBN:urn:nbn:se:slu:epsilon-p-113118
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113118
Additional ID:
Type of IDID
DOI10.1371/journal.pone.0252954
Web of Science (WoS)000664642700073
ID Code:25068
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:27 Aug 2021 08:25
Metadata Last Modified:27 Aug 2021 08:31

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