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Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up

Saellström, Sara and Sadeghi, Arian and Eriksson, Emma and Segall, Thomas and Dimopoulou, Maria and Korsgren, Olle and Loskog, Angelica SI. and Totterman, Thomas H. and Hemminki, Akseli and Rönnberg, Henrik (2021). Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up. Frontiers in Veterinary Science. 8 , 695222
[Research article]

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Abstract

Malignant melanoma is a serious disease in both humans and dogs, and the high metastatic potential results in poor prognosis for many patients. Its similarities with human melanoma make spontaneous canine melanoma an excellent model for comparative studies of novel therapies and tumor biology. Gene therapy using adenoviruses encoding the immunostimulatory gene CD40L (AdCD40L) has shown promise in initial clinical trials enrolling human patients with various malignancies including melanoma. We report a study of local AdCD40L treatment in 32 cases of canine melanoma (23 oral, 5 cutaneous, 3 ungual and 1 conjunctival). Eight patients were World Health Organization (WHO) stage I, 9 were stage II, 12 stage III, and 3 stage IV. One to six intratumoral injections of AdCD40L were given every seven days, combined with cytoreductive surgery in 20 cases and only immunotherapy in 12 cases. Tumor tissue was infiltrated with T and B lymphocytes after treatment, suggesting immune stimulation. The best overall response based on result of immunotherapy included 7 complete responses, 5 partial responses, 5 stable and 2 progressive disease statuses according to the World Health Organization response criteria. Median survival was 285 days (range 20-3435 d). Our results suggest that local AdCD40L therapy is safe and could have beneficial effects in dogs, supporting further treatment development. Clinical translation to human patients is ongoing.

Authors/Creators:Saellström, Sara and Sadeghi, Arian and Eriksson, Emma and Segall, Thomas and Dimopoulou, Maria and Korsgren, Olle and Loskog, Angelica SI. and Totterman, Thomas H. and Hemminki, Akseli and Rönnberg, Henrik
Title:Adenoviral CD40 Ligand Immunotherapy in 32 Canine Malignant Melanomas-Long-Term Follow Up
Series Name/Journal:Frontiers in Veterinary Science
Year of publishing :2021
Volume:8
Article number:695222
Number of Pages:12
Publisher:FRONTIERS MEDIA SA
ISSN:2297-1769
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:immuno oncology, adenoviral vectors, translational medicine, canine malignant melanoma, clinical trials, AdCD40L
URN:NBN:urn:nbn:se:slu:epsilon-p-113140
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113140
Additional ID:
Type of IDID
DOI10.3389/fvets.2021.695222
Web of Science (WoS)000681639000001
ID Code:25081
Faculty:University Animal Hospital
VH - Faculty of Veterinary Medicine and Animal Science
Department:University Animal Hospital (UAH)
(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:27 Aug 2021 14:59
Metadata Last Modified:27 Aug 2021 15:01

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