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Dispersal strategies shape persistence and evolution of human gut bacteria

Hildebrand, Falk and Gossmann, Toni and Frioux, Clemence and Ozkurt, Ezgi and Myers, Pernille Neve and Ferretti, Pamela and Kuhn, Michael and Bahram, Mohammad and Nielsen, Henrik Bjørn and Bork, Peer (2021). Dispersal strategies shape persistence and evolution of human gut bacteria. . 29 , 1167-1176
[Research article]

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Abstract

Human gut bacterial strains can co-exist with their hosts for decades, but little is known about how these microbes persist and disperse, and evolve thereby. Here, we examined these processes in 5,278 adult and infant fecal metagenomes, longitudinally sampled in individuals and families. Our analyses revealed that a subset of gut species is extremely persistent in individuals, families, and geographic regions, represented often by locally successful strains of the phylum Bacteroidota. These ''tenacious'' bacteria show high levels of genetic adaptation to the human host but a high probability of loss upon antibiotic interventions. By contrast, heredipersistent bacteria, notably Firmicutes, often rely on dispersal strategies with weak phylogeographic patterns but strong family transmissions, likely related to sporulation. These analyses describe how different dispersal strategies can lead to the long-term persistence of human gut microbes with implications for gut flora modulations.

Authors/Creators:Hildebrand, Falk and Gossmann, Toni and Frioux, Clemence and Ozkurt, Ezgi and Myers, Pernille Neve and Ferretti, Pamela and Kuhn, Michael and Bahram, Mohammad and Nielsen, Henrik Bjørn and Bork, Peer
Title:Dispersal strategies shape persistence and evolution of human gut bacteria
Year of publishing :2021
Volume:29
Page range:1167-1176
Number of Pages:19
Publisher:CELL PRESS
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Microbiology (Microbiology in the medical area to be 30109)
URN:NBN:urn:nbn:se:slu:epsilon-p-113161
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113161
Additional ID:
Type of IDID
DOI10.1016/j.chom.2021.05.008
Web of Science (WoS)000672821500018
ID Code:25089
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Ecology
(S) > Dept. of Ecology
Deposited By: SLUpub Connector
Deposited On:30 Aug 2021 07:26
Metadata Last Modified:30 Aug 2021 07:31

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