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Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe

Rossi, Chiara and Zadra, Nicola and Fevola, Cristina and Ecke, Frauke and Hörnfeldt, Birger and Kallies, Rene and Kazimirova, Maria and Magnusson, Magnus and Olsson, Gert and Ulrich, Rainer G. and Jaaskelainen, Anne J. and Henttonen, Heikki and Hauffe, Heidi C. (2021). Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe. Viruses. 13 , 1317
[Research article]

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Abstract

The picornavirus named 'Ljungan virus' (LV, species Parechovirus B) has been detected in a dozen small mammal species from across Europe, but detailed information on its genetic diversity and host specificity is lacking. Here, we analyze the evolutionary relationships of LV variants circulating in free-living mammal populations by comparing the phylogenetics of the VP1 region (encoding the capsid protein and associated with LV serotype) and the 3D(pol) region (encoding the RNA polymerase) from 24 LV RNA-positive animals and a fragment of the 5 ' untranslated region (UTR) sequence (used for defining strains) in sympatric small mammals. We define three new VP1 genotypes: two in bank voles (Myodes glareolus) (genotype 8 from Finland, Sweden, France, and Italy, and genotype 9 from France and Italy) and one in field voles (Microtus arvalis) (genotype 7 from Finland). There are several other indications that LV variants are host-specific, at least in parts of their range. Our results suggest that LV evolution is rapid, ongoing and affected by genetic drift, purifying selection, spillover and host evolutionary history. Although recent studies suggest that LV does not have zoonotic potential, its widespread geographical and host distribution in natural populations of well-characterized small mammals could make it useful as a model for studying RNA virus evolution and transmission.

Authors/Creators:Rossi, Chiara and Zadra, Nicola and Fevola, Cristina and Ecke, Frauke and Hörnfeldt, Birger and Kallies, Rene and Kazimirova, Maria and Magnusson, Magnus and Olsson, Gert and Ulrich, Rainer G. and Jaaskelainen, Anne J. and Henttonen, Heikki and Hauffe, Heidi C.
Title:Evolutionary Relationships of Ljungan Virus Variants Circulating in Multi-Host Systems across Europe
Series Name/Journal:Viruses
Year of publishing :2021
Volume:13
Article number:1317
Number of Pages:18
Publisher:MDPI
ISSN:1999-4915
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology
Keywords:Picornaviridae, Parechovirus B, Ljungan virus isolates, small mammals, rodent-borne virus, zoonosis, bank vole
URN:NBN:urn:nbn:se:slu:epsilon-p-113241
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113241
Additional ID:
Type of IDID
DOI10.3390/v13071317
Web of Science (WoS)000677027800001
ID Code:25126
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:31 Aug 2021 07:25
Metadata Last Modified:31 Aug 2021 07:31

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