Home About Browse Search
Svenska


Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe

Schneider, Julia and Hoffmann, Bernd and Fevola, Cristina and Schmidt, Marie Luisa and Imholt, Christian and Fischer, Stefan and Ecke, Frauke and Hörnfeldt, Birger and Magnusson, Magnus and Olsson, Gert and Rizzoli, Annapaola and Tagliapietra, Valentina and Chiari, Mario and Reusken, Chantal and Buzan, Elena and Kazimirova, Maria and Stanko, Michal and White, Thomas A. and Reil, Daniela and Obiegala, Anna and Meredith, Anna and Drexler, Jan Felix and Essbauer, Sandra and Henttonen, Heikki and Jacob, Jens and Hauffe, Heidi C. and Beer, Martin and Heckel, Gerald and Ulrich, Rainer G. (2021). Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe. Viruses. 13 , 1258
[Research article]

[img] PDF
1MB

Abstract

The development of new diagnostic methods resulted in the discovery of novel hepaciviruses in wild populations of the bank vole (Myodes glareolus, syn. Clethrionomys glareolus). The naturally infected voles demonstrate signs of hepatitis similar to those induced by hepatitis C virus (HCV) in humans. The aim of the present research was to investigate the geographical distribution of bank vole-associated hepaciviruses (BvHVs) and their genetic diversity in Europe. Real-time reverse transcription polymerase chain reaction (RT-qPCR) screening revealed BvHV RNA in 442 out of 1838 (24.0%) bank voles from nine European countries and in one of seven northern red-backed voles (Myodes rutilus, syn. Clethrionomys rutilus). BvHV RNA was not found in any other small mammal species (n = 23) tested here. Phylogenetic and isolation-by-distance analyses confirmed the occurrence of both BvHV species (Hepacivirus F and Hepacivirus J) and their sympatric occurrence at several trapping sites in two countries. The broad geographical distribution of BvHVs across Europe was associated with their presence in bank voles of different evolutionary lineages. The extensive geographical distribution and high levels of genetic diversity of BvHVs, as well as the high population fluctuations of bank voles and occasional commensalism in some parts of Europe warrant future studies on the zoonotic potential of BvHVs.

Authors/Creators:Schneider, Julia and Hoffmann, Bernd and Fevola, Cristina and Schmidt, Marie Luisa and Imholt, Christian and Fischer, Stefan and Ecke, Frauke and Hörnfeldt, Birger and Magnusson, Magnus and Olsson, Gert and Rizzoli, Annapaola and Tagliapietra, Valentina and Chiari, Mario and Reusken, Chantal and Buzan, Elena and Kazimirova, Maria and Stanko, Michal and White, Thomas A. and Reil, Daniela and Obiegala, Anna and Meredith, Anna and Drexler, Jan Felix and Essbauer, Sandra and Henttonen, Heikki and Jacob, Jens and Hauffe, Heidi C. and Beer, Martin and Heckel, Gerald and Ulrich, Rainer G.
Title:Geographical Distribution and Genetic Diversity of Bank Vole Hepaciviruses in Europe
Series Name/Journal:Viruses
Year of publishing :2021
Volume:13
Article number:1258
Number of Pages:14
Publisher:MDPI
ISSN:1999-4915
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Microbiology (Microbiology in the medical area to be 30109)
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology
Keywords:bank vole hepaciviruses, HCV, Hepacivirus F, Hepacivirus J, rodent-borne pathogen, Europe, emerging virus
URN:NBN:urn:nbn:se:slu:epsilon-p-113242
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113242
Additional ID:
Type of IDID
DOI10.3390/v13071258
Web of Science (WoS)000677079300001
ID Code:25127
Faculty:S - Faculty of Forest Sciences
Department:(S) > Dept. of Wildlife, Fish and Environmental Studies
Deposited By: SLUpub Connector
Deposited On:31 Aug 2021 10:25
Metadata Last Modified:31 Aug 2021 10:31

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits