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Thyroid function and immune status in perch (Perca fluviatilis) from lakes contaminated with PFASs or PCBs

Birgersson, Lina and Jouve, Justin and Jonsson, Elisabeth and Asker, Noomi and Andreasson, Fredrik and Golovko, Oksana and Ahrens, Lutz and Sturve, Joachim (2021). Thyroid function and immune status in perch (Perca fluviatilis) from lakes contaminated with PFASs or PCBs. Ecotoxicology and Environmental Safety. 222 , 112495
[Research article]

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Abstract

The environment contains a multitude of man-made chemicals, some of which can act as endocrine disruptors (EDCs), while others can be immunotoxic. We evaluated thyroid disruption and immunotoxic effects in wild female perch (Perca fluviatilis) collected from two contaminated areas in Sweden; one site contaminated with perand polyfluoroalkyl substances (PFASs) and two sites contaminated with polychlorinated biphenyls (PCBs), with one reference site included for each area. The hepatic mRNA expression of thyroid receptors alpha and beta, and the thyroid hormone metabolising iodothyronine deiodinases (dio1, dio2 and dio3) were measured using real-time PCR, while the levels of thyroid hormone T3 in plasma was analysed using a radioimmunoassay. In addition, lymphocytes, granulocytes, and thrombocytes were counted microscopically. Our results showed lower levels of T3 as well as lower amounts of lymphocytes and granulocytes in perch collected from the PFAS-contaminated site compared to reference sites. In addition, expressions of mRNA coding for thyroid hormone metabolising enzymes (dio2 and dio3) and thyroid receptor alpha (thra) were significantly different in these fish compared to their reference site. For perch collected at the two PCB-contaminated sites, there were no significant differences in T3 levels or in expression levels of the thyroid-related genes, compared to the reference fish. Fish from one of the PCB-contaminated sites had higher levels of thrombocytes compared with both the second PCB lake and their reference lake; hence PCBs are unlikely to be the cause of this effect. The current study suggests that lifelong exposure to PFASs could affect both the thyroid hormone status and immune defence of perch in the wild.

Authors/Creators:Birgersson, Lina and Jouve, Justin and Jonsson, Elisabeth and Asker, Noomi and Andreasson, Fredrik and Golovko, Oksana and Ahrens, Lutz and Sturve, Joachim
Title:Thyroid function and immune status in perch (Perca fluviatilis) from lakes contaminated with PFASs or PCBs
Series Name/Journal:Ecotoxicology and Environmental Safety
Year of publishing :2021
Volume:222
Article number:112495
Number of Pages:9
Publisher:ACADEMIC PRESS INC ELSEVIER SCIENCE
ISSN:0147-6513
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:European perch, Thyroid disruption, Immunotoxicity PFASs, PCBs
URN:NBN:urn:nbn:se:slu:epsilon-p-113262
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113262
Additional ID:
Type of IDID
DOI10.1016/j.ecoenv.2021.112495
Web of Science (WoS)000679980300006
ID Code:25138
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Aquatic Sciences and Assessment
Deposited By: SLUpub Connector
Deposited On:01 Sep 2021 06:26
Metadata Last Modified:01 Sep 2021 06:31

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