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Evaluation of antibodies in cerebrospinal fluid for the diagnosis of tick-borne encephalitis in dogs

Alnefelt, Yvonne and Van Meervenne, Sofie and Varjonen, Katarina and Tidholm, Anna and Rohdin, Cecilia (2021). Evaluation of antibodies in cerebrospinal fluid for the diagnosis of tick-borne encephalitis in dogs. Acta Veterinaria Scandinavica. 63 , 32
[Research article]

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Abstract

Tick-borne encephalitis (TBE) is caused by the neurotropic tick-borne encephalitis virus (TBEV). In dogs, this virus may affect the central nervous system (CNS), causing meningoencephalitis, meningomyelitis, radiculitis or any combination of these. Diagnosis of TBE relies on a combination of clinical signs of CNS disease and laboratory findings, including CSF pleocytosis and serum TBEV antibody titers. Exposure to TBEV does not necessarily cause clinical disease, and seroprevalence has been reported as high as 40% in endemic areas. This causes concerns of over-diagnosing TBE in dogs with CNS disease. By examining TBEV antibodies in dogs with and without neurological disease in a TBEV endemic area, this study aimed to evaluate the diagnostic value of TBEV antibodies in the cerebrospinal fluid (CSF) in dogs. Eighty-nine dogs were included in the study, 56 with neurological disease and 33 neurologically normal control dogs. A positive TBEV CSF and serum IgG antibody titer (> 126 U/mL) was found in 3/89 dogs (3.4%). A positive serum TBEV antibody titer was found in 11 of the 89 dogs (12.4%). None of the control dogs showed a positive CSF antibody titer, whilst two showed positive serum concentrations. A positive CSF IgG antibody titer supports a clinical diagnosis of TBE in patients with acute onset of CNS disease and may help reduce the risk of over-diagnosis.

Authors/Creators:Alnefelt, Yvonne and Van Meervenne, Sofie and Varjonen, Katarina and Tidholm, Anna and Rohdin, Cecilia
Title:Evaluation of antibodies in cerebrospinal fluid for the diagnosis of tick-borne encephalitis in dogs
Series Name/Journal:Acta Veterinaria Scandinavica
Year of publishing :2021
Volume:63
Article number:32
Number of Pages:4
Publisher:BMC
ISSN:0044-605X
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Canine, Meningoencephalitis, Meningoencephalomyelitis, Serology, Virus
URN:NBN:urn:nbn:se:slu:epsilon-p-113508
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113508
Additional ID:
Type of IDID
DOI10.1186/s13028-021-00597-9
Web of Science (WoS)000690972000002
ID Code:25298
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:10 Sep 2021 10:25
Metadata Last Modified:10 Sep 2021 10:31

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