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Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma

Ulfstedt, Johan Mattsson and Venge, Per and Holmgren, Sofia and Enblad, Gunilla and Eriksson, Staffan and Molin, Daniel (2021). Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma. Upsala Journal of Medical Sciences. 126 , e6119
[Research article]

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Abstract

Background: Thymidine kinase 1 (TK1) is an intracellular protein associated with DNA synthesis, expressed during the G1 phase and remained elevated through the M phase, with a potential as a biomarker for cell proliferation. In this study, we explore the possible use of TK1 in Hodgkin lymphoma (HL).Methods: Serum concentrations of TK1 (S-TK1) were measured in 46 newly diagnosed HL patients using prospectively collected biobanked serum samples. The samples were analyzed using a novel antibody-based TK1 immunosorbent assay (ELISA).Results: The concentrations of S-TK1 were elevated in HL patients compared with healthy controls (median 0.32 mu g/L vs. 0.24 mu g/L, P = 0.003). A further increase in S-TK1 was observed during the treatment. The S-TK1 concentrations were higher in patients with advanced stage disease, low B-Hb, elevated P-LD and in those with B-symptoms. A high ESR correlated with low S-TK1.Conclusions: The study results suggest that S-TK1, measured using a novel antibody-based assay, has the potential to be a biomarker in HL. However, while S-TK1 levels are elevated at baseline compared with healthy controls, a limited number of patients and comparatively short follow-up time render reliable -conclusions difficult.

Authors/Creators:Ulfstedt, Johan Mattsson and Venge, Per and Holmgren, Sofia and Enblad, Gunilla and Eriksson, Staffan and Molin, Daniel
Title:Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma
Series Name/Journal:Upsala Journal of Medical Sciences
Year of publishing :2021
Volume:126
Article number:e6119
Number of Pages:6
Publisher:UPSALA MED SOC
ISSN:0300-9734
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Immunology in the medical area
Keywords:Hodgkin lymphoma, TK1, Thymidine kinase, prognostic markers, chemotherapy
URN:NBN:urn:nbn:se:slu:epsilon-p-113512
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113512
Additional ID:
Type of IDID
DOI10.48101/ujms.v126.6119
Web of Science (WoS)000689142600001
ID Code:25301
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:10 Sep 2021 11:25
Metadata Last Modified:10 Sep 2021 11:31

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