Ulfstedt, Johan Mattsson and Venge, Per and Holmgren, Sofia and Enblad, Gunilla and Eriksson, Staffan and Molin, Daniel
(2021).
Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma.
Upsala Journal of Medical Sciences. 126
, e6119
[Research article]
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Abstract
Background: Thymidine kinase 1 (TK1) is an intracellular protein associated with DNA synthesis, expressed during the G1 phase and remained elevated through the M phase, with a potential as a biomarker for cell proliferation. In this study, we explore the possible use of TK1 in Hodgkin lymphoma (HL).Methods: Serum concentrations of TK1 (S-TK1) were measured in 46 newly diagnosed HL patients using prospectively collected biobanked serum samples. The samples were analyzed using a novel antibody-based TK1 immunosorbent assay (ELISA).Results: The concentrations of S-TK1 were elevated in HL patients compared with healthy controls (median 0.32 mu g/L vs. 0.24 mu g/L, P = 0.003). A further increase in S-TK1 was observed during the treatment. The S-TK1 concentrations were higher in patients with advanced stage disease, low B-Hb, elevated P-LD and in those with B-symptoms. A high ESR correlated with low S-TK1.Conclusions: The study results suggest that S-TK1, measured using a novel antibody-based assay, has the potential to be a biomarker in HL. However, while S-TK1 levels are elevated at baseline compared with healthy controls, a limited number of patients and comparatively short follow-up time render reliable -conclusions difficult.
Authors/Creators: | Ulfstedt, Johan Mattsson and Venge, Per and Holmgren, Sofia and Enblad, Gunilla and Eriksson, Staffan and Molin, Daniel | ||||||
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Title: | Serum concentrations of Thymidine kinase 1 measured using a novel antibody-based assay in patients with Hodgkin Lymphoma | ||||||
Series Name/Journal: | Upsala Journal of Medical Sciences | ||||||
Year of publishing : | 2021 | ||||||
Volume: | 126 | ||||||
Article number: | e6119 | ||||||
Number of Pages: | 6 | ||||||
Publisher: | UPSALA MED SOC | ||||||
ISSN: | 0300-9734 | ||||||
Language: | English | ||||||
Publication Type: | Research article | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Immunology in the medical area | ||||||
Keywords: | Hodgkin lymphoma, TK1, Thymidine kinase, prognostic markers, chemotherapy | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-113512 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113512 | ||||||
Additional ID: |
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ID Code: | 25301 | ||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
Department: | (VH) > Dept. of Anatomy, Physiology and Biochemistry | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 10 Sep 2021 11:25 | ||||||
Metadata Last Modified: | 10 Sep 2021 11:31 |
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