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Fecal Short-Chain Fatty Acid Ratios as Related to Gastrointestinal and Depressive Symptoms in Young Adults

Müller, Bettina and Rasmusson, Annica J. and Just, David and Bannak Gedara, Shishanthi Jayarathna and Moazzami, Ali and Novicic, Zorana Kurbalija and Cunningham, Janet L. (2021). Fecal Short-Chain Fatty Acid Ratios as Related to Gastrointestinal and Depressive Symptoms in Young Adults. Psychosomatic medicine. 83 , 693-699
[Research article]

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Abstract

Objective: Short-chain fatty acids (SCFAs) are produced by the gut microbiota and may reflect health. Gut symptoms are common in individuals with depressive disorders, and recent data indicate relationships between gut microbiota and psychiatric health. We aimed to investigate potential associations between SCFAs and self-reported depressive and gut symptoms in young adults.Methods: Fecal samples from 164 individuals (125 were patients with psychiatric disorders: mean [standard deviation] age = 21.9 [2.6] years, 14% men; 39 nonpsychiatric controls: age = 28.5 [9.5] years, 38% men) were analyzed for the SCFA acetate, butyrate, and propionate by nuclear magnetic resonance spectroscopy. We then compared SCFA ratios with dimensional measures of self-reported depressive and gut symptoms.Results: Depressive symptoms showed a positive association with acetate levels (rho = 0.235, p =.003) and negative associations with both butyrate (rho = -0.195, p =.014) and propionate levels (rho = -0.201, p =.009) in relation to total SCFA levels. Furthermore, symptoms of diarrhea showed positive associations with acetate (rho = 0.217, p =.010) and negative associations with propionate in relation to total SCFA levels (rho = 0.229, p = 0-007). Cluster analysis revealed a heterogeneous pattern where shifts in SCFA ratios were observed in individuals with elevated levels of depressive symptoms, elevated levels of gut symptoms, or both.Conclusions: Shifts in SCFAs are associated with both depressive symptoms and gut symptoms in young adults and may have of relevance for treatment.

Authors/Creators:Müller, Bettina and Rasmusson, Annica J. and Just, David and Bannak Gedara, Shishanthi Jayarathna and Moazzami, Ali and Novicic, Zorana Kurbalija and Cunningham, Janet L.
Title:Fecal Short-Chain Fatty Acid Ratios as Related to Gastrointestinal and Depressive Symptoms in Young Adults
Series Name/Journal:Psychosomatic medicine
Year of publishing :2021
Volume:83
Page range:693-699
Number of Pages:7
Publisher:LIPPINCOTT WILLIAMS AND WILKINS
ISSN:0033-3174
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Psychiatry
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Microbiology in the medical area
Keywords:depressive disorders, gut microbiota, NMR, SCFA, gut symptoms
URN:NBN:urn:nbn:se:slu:epsilon-p-113594
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113594
Additional ID:
Type of IDID
DOI10.1097/PSY.0000000000000965
Web of Science (WoS)000692194200009
ID Code:25375
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:17 Sep 2021 10:12
Metadata Last Modified:17 Sep 2021 10:21

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