Home About Browse Search
Svenska


Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?

Buemann, Benjamin and Marazziti, Donatella and Uvnäs-Moberg, Kerstin (2021). Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients? The World Journal of Biological Psychiatry. 22 , 387-398
[Research article]

[img] PDF
1MB

Abstract

Objectives Based on its well-documented anti-inflammatory and restorative properties we propose trials with the natural hormone oxytocin for treatment of hospitalised Covid-19 patients. Methods We searched for, retrieved, and commented on specific literature regarding multiple functions of oxytocin with a special focus on its modulation of inflammatory, immune, and restorative functions. Results Available data gathered in animals and humans support the anti-inflammatory properties of oxytocin. The multiple anti-inflammatory effects of oxytocin have been demonstrated in vitro and in vivo in various animal models and also in humans in response to intravenous infusion of oxytocin. Furthermore, oxytocin has been documented to activate several types of protective and restorative mechanisms and to exert positive effects on the immune system. Conclusions In addition, to being anti-inflammatory, it may be hypothesised, that oxytocin may be less suppressive on adaptive immune systems, as compared with glucocorticoids. Finally, by its restorative effects coupled with its anti-stress and healing properties, oxytocin may shorten the recovery period of the Covid-19 patients.

Authors/Creators:Buemann, Benjamin and Marazziti, Donatella and Uvnäs-Moberg, Kerstin
Title:Can intravenous oxytocin infusion counteract hyperinflammation in COVID-19 infected patients?
Series Name/Journal:The World Journal of Biological Psychiatry
Year of publishing :2021
Volume:22
Page range:387-398
Number of Pages:12
Publisher:TAYLOR AND FRANCIS LTD
ISSN:1562-2975
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Immunology in the medical area
Keywords:Oxytocin, inflammation, anti-inflammatory, immune system, restorative, Covid-19, clinical trials
URN:NBN:urn:nbn:se:slu:epsilon-p-108096
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-108096
Additional ID:
Type of IDID
DOI10.1080/15622975.2020.1814408
Web of Science (WoS)000568823100001
ID Code:25456
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Environment and Health
Deposited By: SLUpub Connector
Deposited On:20 Sep 2021 09:25
Metadata Last Modified:20 Sep 2021 09:31

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits