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Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum

Hien, Domonbabele F. D. S. and Pare, Prisca S. L. and Cooper, Amanda and Koama, Benjamin K. and Guissou, Edwige and Yameogo, Koudraogo B. and Yerbanga, Rakiswende S. and Farrell, Iain W. and Ouedraogo, Jean B. and Gnankine, Olivier and Ignell, Rickard and Cohuet, Anna and Dabire, Roch K. and Stevenson, Philip C. and Lefevre, Thierry (2021). Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum. Parasites and Vectors. 14 , 479
[Research article]

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Abstract

Background: Besides feeding on blood, females of the malaria vector Anopheles gambiae sensu lato readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean Ricinus communis, on the ability of mosquitoes to transmit Plasmodium falciparum.Methods: Females of Anopheles gambiae and its sibling species Anopheles coluzzii were exposed to ricinine through sugar feeding assays to assess the effect of this phytochemical on mosquito survival, level of P. falciparum infection and growth rate of the parasite.Results: Ricinine induced a significant reduction in the longevity of both Anopheles species. Ricinine caused acceleration in the parasite growth rate with an earlier invasion of the salivary glands in both species. At a concentration of 0.04 g l(-1) in An. coluzzii, ricinine had no effect on mosquito infection, while 0.08 g l(-1) ricinine-5% glucose solution induced a 14% increase in An. gambiae infection rate.Conclusions: Overall, our findings reveal that consumption of certain nectar phytochemicals can have unexpected and contrasting effects on key phenotypic traits that govern the intensity of malaria transmission. Further studies will be required before concluding on the putative role of ricinine as a novel control agent, including the development of ricinine-based toxic and transmission-blocking sugar baits. Testing other secondary phytochemicals in plant nectar will provide a broader understanding of the impact which plants can have on the transmission of vector-borne diseases.

Authors/Creators:Hien, Domonbabele F. D. S. and Pare, Prisca S. L. and Cooper, Amanda and Koama, Benjamin K. and Guissou, Edwige and Yameogo, Koudraogo B. and Yerbanga, Rakiswende S. and Farrell, Iain W. and Ouedraogo, Jean B. and Gnankine, Olivier and Ignell, Rickard and Cohuet, Anna and Dabire, Roch K. and Stevenson, Philip C. and Lefevre, Thierry
Title:Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum
Series Name/Journal:Parasites and Vectors
Year of publishing :2021
Volume:14
Article number:479
Number of Pages:11
Publisher:BMC
ISSN:1756-3305
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Ecology
(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Zoology
Keywords:Plasmodium falciparum, Anopheles coluzzii, Anopheles gambiae, Ricinine, Malaria transmission, Transmission-blocking strategies
URN:NBN:urn:nbn:se:slu:epsilon-p-113762
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113762
Additional ID:
Type of IDID
DOI10.1186/s13071-021-04992-z
Web of Science (WoS)000696222200003
ID Code:25556
Faculty:LTV - Fakulteten för landskapsarkitektur, trädgårds- och växtproduktionsvetenskap
Department:(LTJ, LTV) > Department of Plant Protection Biology
Deposited By: SLUpub Connector
Deposited On:05 Oct 2021 08:25
Metadata Last Modified:05 Oct 2021 08:31

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