Hien, Domonbabele F. D. S. and Pare, Prisca S. L. and Cooper, Amanda and Koama, Benjamin K. and Guissou, Edwige and Yameogo, Koudraogo B. and Yerbanga, Rakiswende S. and Farrell, Iain W. and Ouedraogo, Jean B. and Gnankine, Olivier and Ignell, Rickard and Cohuet, Anna and Dabire, Roch K. and Stevenson, Philip C. and Lefevre, Thierry
(2021).
Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum.
Parasites and Vectors. 14
, 479
[Research article]
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Abstract
Background: Besides feeding on blood, females of the malaria vector Anopheles gambiae sensu lato readily feed on natural sources of plant sugars. The impact of toxic secondary phytochemicals contained in plant-derived sugars on mosquito physiology and the development of Plasmodium parasites remains elusive. The focus of this study was to explore the influence of the alkaloid ricinine, found in the nectar of the castor bean Ricinus communis, on the ability of mosquitoes to transmit Plasmodium falciparum.Methods: Females of Anopheles gambiae and its sibling species Anopheles coluzzii were exposed to ricinine through sugar feeding assays to assess the effect of this phytochemical on mosquito survival, level of P. falciparum infection and growth rate of the parasite.Results: Ricinine induced a significant reduction in the longevity of both Anopheles species. Ricinine caused acceleration in the parasite growth rate with an earlier invasion of the salivary glands in both species. At a concentration of 0.04 g l(-1) in An. coluzzii, ricinine had no effect on mosquito infection, while 0.08 g l(-1) ricinine-5% glucose solution induced a 14% increase in An. gambiae infection rate.Conclusions: Overall, our findings reveal that consumption of certain nectar phytochemicals can have unexpected and contrasting effects on key phenotypic traits that govern the intensity of malaria transmission. Further studies will be required before concluding on the putative role of ricinine as a novel control agent, including the development of ricinine-based toxic and transmission-blocking sugar baits. Testing other secondary phytochemicals in plant nectar will provide a broader understanding of the impact which plants can have on the transmission of vector-borne diseases.
Authors/Creators: | Hien, Domonbabele F. D. S. and Pare, Prisca S. L. and Cooper, Amanda and Koama, Benjamin K. and Guissou, Edwige and Yameogo, Koudraogo B. and Yerbanga, Rakiswende S. and Farrell, Iain W. and Ouedraogo, Jean B. and Gnankine, Olivier and Ignell, Rickard and Cohuet, Anna and Dabire, Roch K. and Stevenson, Philip C. and Lefevre, Thierry | ||||||
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Title: | Contrasting effects of the alkaloid ricinine on the capacity of Anopheles gambiae and Anopheles coluzzii to transmit Plasmodium falciparum | ||||||
Series Name/Journal: | Parasites and Vectors | ||||||
Year of publishing : | 2021 | ||||||
Volume: | 14 | ||||||
Article number: | 479 | ||||||
Number of Pages: | 11 | ||||||
Publisher: | BMC | ||||||
ISSN: | 1756-3305 | ||||||
Language: | English | ||||||
Publication Type: | Research article | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Ecology (A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Zoology | ||||||
Keywords: | Plasmodium falciparum, Anopheles coluzzii, Anopheles gambiae, Ricinine, Malaria transmission, Transmission-blocking strategies | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-113762 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113762 | ||||||
Additional ID: |
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ID Code: | 25556 | ||||||
Faculty: | LTV - Fakulteten för landskapsarkitektur, trädgårds- och växtproduktionsvetenskap | ||||||
Department: | (LTJ, LTV) > Department of Plant Protection Biology | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 05 Oct 2021 08:25 | ||||||
Metadata Last Modified: | 05 Oct 2021 08:31 |
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