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Cashew Gum (Anacardium occidentale) as a Potential Source for the Production of Tocopherol-Loaded Nanoparticles: Formulation, Release Profile and Cytotoxicity

Loureiro, Kahynna C. and Jager, Alessandro and Pavlova, Ewa and Lima Verde, Isabel and Stepanek, Petr and Sangenito, Leandro S. and Santos, Andre L. S. and Chaud, Marco V. and Barud, Hernane S. and Soares, Monica F. La R. and De Albuquerque-Junior, Ricardo L. C. and Cardoso, Juliana C. and Souto, Eliana B. and Mendonca, Marcelo da Costa and Severino, Patricia (2021). Cashew Gum (Anacardium occidentale) as a Potential Source for the Production of Tocopherol-Loaded Nanoparticles: Formulation, Release Profile and Cytotoxicity. Applied Sciences. 11 , 8467
[Research article]

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Abstract

Every year, more than thirty thousand tons of Cashew gum (Anacardium occidentale, family: Anacardiaceae) are produced in Brazil; however, only a small amount is used for different applications in foodstuff and in pharmaceutical industries. As a raw material for the production of drug delivery systems, cashew gum is still regarded as an innovative compound worth to be exploited. In this work, cashew gum was extracted from the crude exudate of cashew tree employing four methodologies resulting in a light brown powder in different yields (40.61% to 58.40%). The total ashes (0.34% to 1.05%) and moisture (12.90% to 14.81%) were also dependent on the purification approach. FTIR spectra showed the typical bands of purified cashew gum samples, confirming their suitability for the development of a pharmaceutical product. Cashew gum nanoparticles were produced by nanoprecipitation resulting in particles of low polydispersity (<0.2) and an average size depending on the percentage of the oil. The zeta potential of nanoparticles was found to be below 20 mV, which promotes electrostatic stability. Encapsulation efficiencies were above 99.9%, while loading capacity increased with the increase of the percentage of the oil content of particles. The release of the oil from the nanoparticles followed the Korsmeyer-Peppas kinetics model, while particles did not show any signs of toxicity when tested in three distinct cell lines (LLC-MK2, HepG2, and THP-1). Our study highlights the potential added value of using a protein-, lignans-, and nucleic acids-enriched resin obtained from crude extract as a new raw material for the production of drug delivery systems.

Authors/Creators:Loureiro, Kahynna C. and Jager, Alessandro and Pavlova, Ewa and Lima Verde, Isabel and Stepanek, Petr and Sangenito, Leandro S. and Santos, Andre L. S. and Chaud, Marco V. and Barud, Hernane S. and Soares, Monica F. La R. and De Albuquerque-Junior, Ricardo L. C. and Cardoso, Juliana C. and Souto, Eliana B. and Mendonca, Marcelo da Costa and Severino, Patricia
Title:Cashew Gum (Anacardium occidentale) as a Potential Source for the Production of Tocopherol-Loaded Nanoparticles: Formulation, Release Profile and Cytotoxicity
Series Name/Journal:Applied Sciences
Year of publishing :2021
Volume:11
Article number:8467
Number of Pages:17
Publisher:MDPI
ISSN:2076-3417
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 2 Engineering and Technology > 210 Nano Technology > Nano Technology
Keywords:cashew gum, nanoparticles, tocopherol, resin, drug delivery, nanoprecipitation
URN:NBN:urn:nbn:se:slu:epsilon-p-113895
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113895
Additional ID:
Type of IDID
DOI10.3390/app11188467
Web of Science (WoS)000699570300001
ID Code:25645
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:12 Oct 2021 13:25
Metadata Last Modified:12 Oct 2021 13:31

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