Abstract

Background: Globally, there is growing concern over the impacts of pharmaceuticals and drug manufacturing on aquatic animals, and pharmaceuticals are now recognized as contaminants of emerging environmental concern. In recent years, scientists, environmental managers, and policymakers have been interested in using behavioural endpoints for chemical regulation, given their importance for ftness and survival. The body of research on whether and how pharmaceutical exposure alters the behaviour of aquatic animals has grown exponentially, making it diffcult to get an overview of the results. With an international spotlight on the management of these environmental threats, synthesizing the currently available data is vital to inform managers and policymakers, as well as highlighting areas where more research is needed. This is a protocol for a systematic evidence map (SEM) and serves as an a priori record of our objectives and methodological decisions. Our objectives are to identify, catalogue, and present primary research articles on the efects of human and veterinary pharmaceuticals on aquatic animal behaviour.

Methods: The literature search will be conducted using two electronic databases: Web of Science and Scopus, and we will supplement these searches with additional sources. The search string has been developed using a Population–Exposure–Comparison–Outcome (PECO) framework, to capture articles that used an aquatic organism (P, population) to test the efects of a pharmaceutical (E, exposure) on behaviour (O, outcome). Eligible articles must also have a control group (C, comparison). Articles will be screened in two stages, title and abstract, followed by full-text screening before data extraction. Decision trees have been designed a priori to appraise articles for eligibility at both stages of screening. At both stages, screening each article will be completed by two independent reviewers. Study validity will be appraised but not used as a basis for article inclusion. The information extracted from the eligible articles, along with bibliometric data, will be mapped and displayed. All data associated with this SEM will be publicly available through the Open Science Framework (OSF) and a future project webpage.

Keywords

medicine; neurotoxicology; psychoactive; ecotoxicology; evidence synthesis; fitness

Published in

Environmental Evidence
2021, Volume: 10, number: 1, article number: 26

SLU Authors

• Bertram, Michael

  • Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences
    

• Brodin, Tomas

  • Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences
    

• Cerveny, Daniel

  • Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences
    
  • University of South Bohemia in České Budějovice

• Michelangeli, Marcus

  • Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences
    
  • Monash University

• Sundin, Josefin

  • Department of Aquatic Resources (SLU Aqua), Swedish University of Agricultural Sciences
    

• Mccallum, Erin

  • Department of Wildlife, Fish and Environmental Studies, Swedish University of Agricultural Sciences
    

Associated SLU-program

SLUsystematic


Sustainable Development Goals

Ensure availability and sustainable management of water and sanitation for all
Conserve and sustainably use the oceans, seas and marine resources for sustainable development
Ensure sustainable consumption and production patterns


UKÄ Subject classification

Environmental Sciences


Publication identifier

DOI: https://doi.org/10.1186/s13750-021-00241-z

Permanent link to this page (URI)

https://res.slu.se/id/publ/114025