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In Vivo Versus In Vitro Degradation of a 3D Printed Resorbable Device for Ligation of Vascular Tissue in Horses

Adolfsson, Karin H. and Sjöberg, Ida and Höglund, Odd and Wattle, Ove and Hakkarainen, Minna (2021). In Vivo Versus In Vitro Degradation of a 3D Printed Resorbable Device for Ligation of Vascular Tissue in Horses. Macromolecular Bioscience. 21 , 2100164
[Research article]

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Abstract

A resorbable 3D printed polydioxanone (PDO) device is manufactured to facilitate ligation of vascular tissue during surgery. The device must provide sufficient mechanical performance throughout the healing period. Therefore, degradation and mechanical performance of the device are investigated as a function of in vivo and in vitro aging. During aging the PDO device released cyclic and linear water-soluble products. In vivo aging resulted in higher relative number of linear oligomers in comparison to in vitro aging. A major loss of mechanical performance is observed after only 10 days in vivo and the Young's modulus (E) and tensile strength at break (sigma(b)) decreased by 28% and 54%, respectively. This is in contrast to in vitro aging, where no loss of mechanical properties is observed during the same period. The in vivo aged devices exhibit clear holes in the matrices after 28 days, while apparent cracks are observed first after 140 days in vitro. These results highlight the sensitivity of the degradation process of resorbable devices with regards to the interactions of the device with the surrounding environment (tissues) and demonstrate the importance of in vivo testing as compliment to in vitro testing before clinical use of devices.

Authors/Creators:Adolfsson, Karin H. and Sjöberg, Ida and Höglund, Odd and Wattle, Ove and Hakkarainen, Minna
Title:In Vivo Versus In Vitro Degradation of a 3D Printed Resorbable Device for Ligation of Vascular Tissue in Horses
Series Name/Journal:Macromolecular Bioscience
Year of publishing :2021
Volume:21
Article number:2100164
Number of Pages:12
Publisher:WILEY-V C H VERLAG GMBH
ISSN:1616-5187
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 304 Medical Biotechnology > Biomaterials Science
Keywords:3D printing, biomedical materials, degradation products, polydioxanone, resorbable device
URN:NBN:urn:nbn:se:slu:epsilon-p-113266
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113266
Additional ID:
Type of IDID
DOI10.1002/mabi.202100164
Web of Science (WoS)000680062000001
ID Code:25938
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:25 Oct 2021 07:25
Metadata Last Modified:25 Oct 2021 07:31

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