Home About Browse Search
Svenska


Immune response and gut microbiota of mice on a diet mimicking eating habits of elderly with risk of malnutrition development

Hakansson, Asa and Megaelectra, Afina Nuur Farma and Persson, Jenny and Zhang, Su and Alsanius, Beatrix and Olsson, Marie and Jeppsson, Bengt (2021). Immune response and gut microbiota of mice on a diet mimicking eating habits of elderly with risk of malnutrition development. International Journal of Food Sciences and Nutrition. 72 , 1071-1082
[Research article]

[img] PDF
1MB

Abstract

The number of elderlies is increasing but prevalence of malnutrition has been reported. The aim of the study was to determine the significance of short-term nutritional deficiencies in mice. Immune status was assessed through flow cytometry of leucocytes in Peyer's patches (PP) and mesenteric lymph nodes (MLN), and intestinal microbiota was evaluated by terminal restriction fragment length polymorphism (T-RFLP). C57BL/6NCrl mice fed standard diet (StD) or experimental diet high in fat, and low in carbohydrates, protein, fibre, vitamins, and minerals (ExpD) for 2 or 4 weeks. ExpD-animals gained less weight, increased liver lipids, and developed splenomegaly. Diet affected regulatory T-cells, gut homing receptors and TLR2 and TLR4 in PP and MLN and the microbiota was influenced. Partial least squares models on flow cytometry- and T-RFLP data demonstrated correlations between microbial communities and immune phenotyping. Our model shows similarities to malnourished elderly and interactions between intestinal bacteria and the immune system.

Authors/Creators:Hakansson, Asa and Megaelectra, Afina Nuur Farma and Persson, Jenny and Zhang, Su and Alsanius, Beatrix and Olsson, Marie and Jeppsson, Bengt
Title:Immune response and gut microbiota of mice on a diet mimicking eating habits of elderly with risk of malnutrition development
Series Name/Journal:International Journal of Food Sciences and Nutrition
Year of publishing :2021
Volume:72
Page range:1071-1082
Number of Pages:12
Associated Programs and Other Stakeholders:Z - SLU - Library > Odla mera
ISSN:0963-7486
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Nutrition and Dietetics
Keywords:Diet, malnutrition, elderly, microbiota, immune responses
URN:NBN:urn:nbn:se:slu:epsilon-p-111656
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-111656
Additional ID:
Type of IDID
DOI10.1080/09637486.2021.1906212
Web of Science (WoS)000639019100001
ID Code:26070
Faculty:LTV - Fakulteten för landskapsarkitektur, trädgårds- och växtproduktionsvetenskap
Department:(LTJ, LTV) > Department of Biosystems and Technology (from 130101)
(LTJ, LTV) > Department of Plant Breeding (from 130101)
Deposited By: SLUpub Connector
Deposited On:08 Nov 2021 09:25
Metadata Last Modified:09 Nov 2021 05:01

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits