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Novel prioritisation strategies for evaluation of temporal trends in archived white-tailed sea eagle muscle tissue in non-target screening

Dürig, Wiebke and Alygizakis, Nikiforos A. and Menger, Frank and Golovko, Oksana and Wiberg, Karin and Ahrens, Lutz (2022). Novel prioritisation strategies for evaluation of temporal trends in archived white-tailed sea eagle muscle tissue in non-target screening. Journal of Hazardous Materials. 424 , 127331
[Research article]

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Abstract

Environmental monitoring studies based on target analysis capture only a small fraction of contaminants of emerging concern (CECs) and miss pollutants potentially harmful to wildlife. Environmental specimen banks, with their archived samples, provide opportunities to identify new CECs by temporal trend analysis and nontarget screening. In this study, archived white-tailed sea eagle (Haliaeetus albicilla) muscle tissue was analysed by non-targeted high-resolution mass spectrometry. Univariate statistical tests (Mann-Kendall and Spearman rank) for temporal trend analysis were applied as prioritisation methods. A workflow for non-target data was developed and validated using an artificial time series spiked at five levels with gradient concentrations of selected CECs (n = 243). Pooled eagle muscle tissues collected 1965-2017 were then investigated with an eightpoint time series using the validated screening workflow. Following peak detection, peak alignment, and blank subtraction, 14 409 features were considered for statistical analysis. Prioritisation by time-trend analysis detected 207 features with increasing trends. Following unequivocal molecular formula assignment to prioritised features and further elucidation with MetFrag and EU Massbank, 13 compounds were tentatively identified, of which four were of anthropogenic origin. These results show that it is possible to prioritise new CECs in archived biological samples using univariate statistical approaches.

Authors/Creators:Dürig, Wiebke and Alygizakis, Nikiforos A. and Menger, Frank and Golovko, Oksana and Wiberg, Karin and Ahrens, Lutz
Title:Novel prioritisation strategies for evaluation of temporal trends in archived white-tailed sea eagle muscle tissue in non-target screening
Series Name/Journal:Journal of Hazardous Materials
Year of publishing :2022
Volume:424
Article number:127331
Number of Pages:9
Publisher:ELSEVIER
ISSN:0304-3894
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 105 Earth and Related Environmental Sciences > Environmental Sciences (social aspects to be 507)
Keywords:Non-target analysis, Environmental specimen bank, White-tailed sea eagle, LC-QToF-MS, Temporal trend analysis
URN:NBN:urn:nbn:se:slu:epsilon-p-114319
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114319
Additional ID:
Type of IDID
DOI10.1016/j.jhazmat.2021.127331
Web of Science (WoS)000711685700006
ID Code:26104
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Aquatic Sciences and Assessment
Deposited By: SLUpub Connector
Deposited On:15 Nov 2021 07:25
Metadata Last Modified:15 Nov 2021 07:31

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