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Interleukin 31 and targeted vaccination in a case series of six horses with chronic pruritus

Fettelschoss, V and Olomski, F. and Birkmann, K. and Kuendig, T. M. and Bergvall, Kerstin and Fettelschoss-Gabriel, A. (2021). Interleukin 31 and targeted vaccination in a case series of six horses with chronic pruritus. Equine Veterinary Education. 33 , e490-e500
[Research article]

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Abstract

Chronic pruritus is defined as prolonged itching symptoms associated with a variety of skin conditions. These pruritic conditions clinically manifest in a dermatitis phenotype and commonly are of allergic origin with hypersensitivities towards environmental allergens. Interleukin-31 (IL-31) is a common player in allergic pruritus across species. The objective of the study was evaluation of the clinical efficacy of a therapeutic vaccine targeting IL-31 in horses with chronic pruritus of unknown origin (CPUO) and that could not be explained by insect bite hypersensitivity (IBH). This consecutive case series pilot study included client-owned horses with a long history of CPUO. Four horses affected by year-round CPUO were vaccinated with a vaccine consisting of equine IL-31 (eIL-31) covalently coupled to a virus-like particle (VLP) derived from cucumber mosaic virus containing a tetanus toxoid universal T cell epitope (CuMVTT). Clinical signs and pruritic behaviour were documented by photography and owner questionnaire pre and post vaccination. In addition, in three CPUO horses, levels of IL-31, thymic stromal lymphopoietin (TSLP) and monocyte chemoattractant protein 1 (MCP-1) were quantified from skin punch biopsies. IL-31, TSLP and MCP-1 levels were upregulated in pruritic, alopecic skin lesions compared to healthy skin of the same horse. Clinical signs and pruritic behaviour improved in all four horses upon vaccination with eIL-31-CuMVTT vaccine. The vaccine was well tolerated without safety concerns throughout the study. The main limitations of this study are the absence control treated horses and allergy diagnostics. It was concluded that Anti-IL-31 therapy might be applied as an allergen-independent treatment option for horses with CPUO overcoming the challenges of identifying the allergic trigger.

Authors/Creators:Fettelschoss, V and Olomski, F. and Birkmann, K. and Kuendig, T. M. and Bergvall, Kerstin and Fettelschoss-Gabriel, A.
Title:Interleukin 31 and targeted vaccination in a case series of six horses with chronic pruritus
Series Name/Journal:Equine Veterinary Education
Year of publishing :2021
Volume:33
Page range:e490-e500
Number of Pages:11
Publisher:WILEY
ISSN:0957-7734
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:horse, pruritus, chronic pruritus of unknown origin, IL‐31, TSLP
URN:NBN:urn:nbn:se:slu:epsilon-p-109885
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-109885
Additional ID:
Type of IDID
DOI10.1111/eve.13408
Web of Science (WoS)000597321500001
ID Code:26184
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:22 Nov 2021 09:25
Metadata Last Modified:22 Nov 2021 09:31

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