Home About Browse Search
Svenska


The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus

Schwochow, Doreen and Bornelov, Susanne and Jiang, Tingxing and Li, Jingyi and Gourichon, David and Bed'Hom, Bertrand and Dorshorst, Ben J. and Chuong, Cheng-Ming and Tixier-Boichard, Michele and Andersson, Leif (2021). The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus. Pigment Cell and Melanoma Research. 34 , 1015-1028
[Research article]

[img] PDF
1MB

Abstract

Color patterns within individual feathers are common in birds but little is known about the genetic mechanisms causing such patterns. Here, we investigate the genetic basis for autosomal barring in chicken, a horizontal striping pattern on individual feathers. Using an informative backcross, we demonstrate that the MC1R locus is strongly associated with this phenotype. A deletion at SOX10, underlying the dark brown phenotype on its own, affects the manifestation of the barring pattern. The coding variant L133Q in MC1R is the most likely causal mutation for autosomal barring in this pedigree. Furthermore, a genetic screen across six different breeds showing different patterning phenotypes revealed that the most striking shared characteristics among these breeds were that they all carried the MC1R alleles Birchen or brown. Our data suggest that the presence of activating MC1R mutations enhancing pigment synthesis is an important mechanism underlying pigmentation patterns on individual feathers in chicken. We propose that MC1R and its antagonist ASIP play a critical role for determining within-feather pigmentation patterns in birds by acting as activator and inhibitor possibly in a Turing reaction-diffusion model.

Authors/Creators:Schwochow, Doreen and Bornelov, Susanne and Jiang, Tingxing and Li, Jingyi and Gourichon, David and Bed'Hom, Bertrand and Dorshorst, Ben J. and Chuong, Cheng-Ming and Tixier-Boichard, Michele and Andersson, Leif
Title:The feather pattern autosomal barring in chicken is strongly associated with segregation at the MC1R locus
Series Name/Journal:Pigment Cell and Melanoma Research
Year of publishing :2021
Volume:34
Page range:1015-1028
Number of Pages:14
Publisher:WILEY
ISSN:1755-1471
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:chicken, feather patterning, genetics, MC1R, pigmentation, SOX10
URN:NBN:urn:nbn:se:slu:epsilon-p-112118
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112118
Additional ID:
Type of IDID
DOI10.1111/pcmr.12975
Web of Science (WoS)000646705800001
ID Code:26230
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:29 Nov 2021 11:25
Metadata Last Modified:29 Nov 2021 11:31

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits