Home About Browse Search
Svenska


Changes of adenosine deaminase activity in serum and saliva around parturition in sows with and without postpartum dysgalactia syndrome

Kaiser, Marianne and Dahl, Jan and Jacobsen, Stine and Jacobson, Magdalena and Andersen, Pia Haubro and Bækbo, Poul and Escribano, Damian and Ceron, Jose Joaquin and Tecles, Fernando (2021). Changes of adenosine deaminase activity in serum and saliva around parturition in sows with and without postpartum dysgalactia syndrome. BMC Veterinary Research. 17 , 352
[Research article]

[img] PDF
843kB

Abstract

Background Postpartum dysgalactia syndrome (PDS) is associated with a significantly higher activation of the inflammatory and stress response at parturition than in the healthy sow. Therefore, reliable and possibly non-invasive biomarkers for substantial increases of inflammation are searched to support the PDS diagnosis. This report studies the possible changes of the inflammatory marker enzyme adenosine deaminase (ADA) in serum and saliva of 38 PDS positive sows (PDS+) and 38 healthy sows (PDS-). Sampling was performed every 24 h from 60 h before to 36 h after parturition. Isoenzyme 1 (ADA1) and isoenzyme 2 (ADA2), as well as total ADA (tADA), were measured and their statistical association with several serum and saliva biomarkers of inflammation and stress was investigated. Results Compared to a baseline (60 to 36h prepartum), salivary activities of ADA1, ADA2 and tADA increased significantly over time in both PDS+ and PDS- sows, reaching their peaks after parturition. In serum from PDS- sows, no changes were observed over time in either ADA1, ADA2 or tADA. In PDS+ sows, serum ADA2 activity decreased temporarily after parturition followed by a significant increase compared to baseline. ADA1, ADA2 and tADA were all significantly associated with several inflammatory biomarkers and ADA1 in serum was associated with serum cortisol. Although serum activity was higher in PDS+ than in PDS- sows, the differences were not statistically significant. Further, no difference was noted between the groups in the analyses of saliva. Conclusions Salivary ADA1 and ADA2 increased in all sows after parturition, potentially as a response to the postpartum inflammation. However, no difference in the activity of ADA1, ADA2 and tADA were found between PDS+ and PDS- sows indicating inability to diagnose PDS under the conditions described in this report.

Authors/Creators:Kaiser, Marianne and Dahl, Jan and Jacobsen, Stine and Jacobson, Magdalena and Andersen, Pia Haubro and Bækbo, Poul and Escribano, Damian and Ceron, Jose Joaquin and Tecles, Fernando
Title:Changes of adenosine deaminase activity in serum and saliva around parturition in sows with and without postpartum dysgalactia syndrome
Series Name/Journal:BMC Veterinary Research
Year of publishing :2021
Volume:17
Article number:352
Number of Pages:8
Publisher:BMC
ISSN:1746-6148
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:ADA, Inflammation, PDS, Saliva, Stress
URN:NBN:urn:nbn:se:slu:epsilon-p-114538
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114538
Additional ID:
Type of IDID
DOI10.1186/s12917-021-03067-6
Web of Science (WoS)000720422000001
ID Code:26268
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:02 Dec 2021 15:39
Metadata Last Modified:18 May 2022 00:47

Repository Staff Only: item control page

Downloads

Downloads per year (since September 2012)

View more statistics

Downloads
Hits