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Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya

Obanda, Vincent and Agwanda, Bernard and Blanco Penedo, Isabel and Mwangi, Irene Ann and King’ori, Edward and Omondi, George P. and Ahlm, Clas and Evander, Magnus and Lwande, Olivia Wesula (2021). Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya. Vector-Borne and Zoonotic Diseases. 21 , 809-816
[Research article]

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Abstract

Crimean Congo Hemorrhagic Fever (CCHF) is an emerging tick-borne zoonotic viral disease with the potential of causing public health emergencies. However, less is known about the role of wildlife and livestock in spreading the virus. Therefore, we aimed to assess how the interactions between African buffalo (Syncerus caffer) and cattle may influence the seroprevalence of CCHF across livestock-wildlife management systems in Kenya. The study included archived sera samples from buffalo and cattle from wildlife only habitats (Lake Nakuru National Park and Solio conservancy), open wildlife-livestock integrated habitats (Maasai Mara ecosystem and Meru National Park), and closed wildlife-livestock habitats (Ol Pejeta Conservancy) in Kenya. We analyzed 191 buffalo and 139 cattle sera using IDvet multispecies, double-antigen IgG enzyme-linked immunosorbent assay (ELISA). The seroprevalence toward Crimean Congo hemorrhagic fever virus (CCHFV) was significantly higher for buffalo compared to cattle (75.3% and 28.1%, respectively, p < 0.001). We obtained the highest seroprevalence among buffalo of 92.1% in closed wildlife only systems compared to 28.8% and 46.1% prevalence in closed-integrated and open-integrated systems, respectively. The regression coefficients were all negative for cattle compared to buffalo in both closed-integrated and open-integrated compared to wildlife only system. Our results show that CCHFV circulates among the diverse animal community in Kenya in spatially disconnected foci. The habitat overlap between cattle and buffalo makes cattle a "bridge species" or superspreader host for CCHFV and increases transmission risks to humans. The effect of animal management system on prevalence is depended on tick control on the cattle and not the animal per se. We conclude that buffalo, a host with a longer life span than livestock, is a reservoir and may serve as a sentinel population for longitudinal surveillance of CCHFV.

Authors/Creators:Obanda, Vincent and Agwanda, Bernard and Blanco Penedo, Isabel and Mwangi, Irene Ann and King’ori, Edward and Omondi, George P. and Ahlm, Clas and Evander, Magnus and Lwande, Olivia Wesula
Title:Livestock Presence Influences the Seroprevalence of Crimean Congo Hemorrhagic Fever Virus on Sympatric Wildlife in Kenya
Series Name/Journal:Vector-Borne and Zoonotic Diseases
Year of publishing :2021
Volume:21
Page range:809-816
Number of Pages:8
Publisher:MARY ANN LIEBERT, INC
ISSN:1530-3667
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:None
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:emerging infectious diseases, tick-borne diseases, outbreak, wildlife, Crimean Congo hemorrhagic fever, African buffalo
URN:NBN:urn:nbn:se:slu:epsilon-p-113808
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113808
Additional ID:
Type of IDID
DOI10.1089/vbz.2021.0024
Web of Science (WoS)000698777700001
ID Code:26273
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:06 Dec 2021 10:25
Metadata Last Modified:06 Dec 2021 10:31

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