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Antimicrobial resistance in equine reproduction

Malaluang, Pongpreecha and Wilén, Elin and Lindahl, Johanna and Hansson, Ingrid and Morrell, Jane (2021). Antimicrobial resistance in equine reproduction. Animals. 11 , 3035
[Article Review/Survey]

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Abstract

Bacteria develop resistance to antibiotics following low-level “background” exposure to antimicrobial agents as well as from exposure at therapeutic levels during treatment for bacterial infections. In this review, we look specifically at antimicrobial resistance (AMR) in the equine reproductive tract and its possible origin, focusing particularly on antibiotics in semen extenders used in preparing semen doses for artificial insemination. Our review of the literature indicated that AMR in the equine uterus and vagina were reported worldwide in the last 20 years, in locations as diverse as Europe, India, and the United States. Bacteria colonizing the mucosa of the reproductive tract are transferred to semen during collection; further contamination of the semen may occur during processing, despite strict attention to hygiene at critical control points. These bacteria compete with spermatozoa for nutrients in the semen extender, producing metabolic byproducts and toxins that have a detrimental effect on sperm quality. Potential pathogens such as Klebsiella pneumoniae, Escherichia coli, and Pseudomonas aeruginosa may occasionally cause fertility issues in inseminated mares. Antibiotics are added during semen processing, according to legislation, to impede the growth of these microorganisms but may have a detrimental effect on sperm quality, depending on the antimicrobial agent and concentration used. However, this addition of antibiotics is counter to current recommendations on the prudent use of antibiotics, which recommend that antibiotics should be used only for therapeutic purposes and after establishing bacterial sensitivity. There is some evidence of resistance among bacteria found in semen samples. Potential alternatives to the addition of antibiotics are considered, especially physical removal separation of spermatozoa from bacteria. Suggestions for further research with colloid centrifugation are provided.

Authors/Creators:Malaluang, Pongpreecha and Wilén, Elin and Lindahl, Johanna and Hansson, Ingrid and Morrell, Jane
Title:Antimicrobial resistance in equine reproduction
Series Name/Journal:Animals
Year of publishing :2021
Volume:11
Article number:3035
Number of Pages:13
ISSN:2076-2615
Language:English
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Medical Bioscience
Keywords:antibiotics, resistance mechanisms, sperm quality, uterine health, semen extenders, prudent use of antimicrobia
URN:NBN:urn:nbn:se:slu:epsilon-p-114576
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114576
Additional ID:
Type of IDID
DOI10.3390/ani11113035
ID Code:26321
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:16 Dec 2021 07:25
Metadata Last Modified:16 Dec 2021 07:31

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