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Effect of 1 mg/kg oral prednisolone on biochemical analytes in ten dogs: a cross‑over study

Pettersson, Helena and Ekstrand, Carl and Hillström, Anna and Lilliehöök, Inger (2021). Effect of 1 mg/kg oral prednisolone on biochemical analytes in ten dogs: a cross‑over study. Comparative Clinical Pathology. 30 , 519-528
[Research article]

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Abstract

Prednisolone is used for treatment of inflammatory, allergic, neoplastic, and immune-mediated diseases in dogs. As a glucocorticoid, prednisolone has biochemical effects, which may interfere with the interpretation of biochemistry test results. The aim of this study is to investigate the effects of prednisolone treatment in an anti-inflammatory dose on common biochemical analytes in dogs and to evaluate the clinical relevance of the changes. Ten beagle dogs, enrolled in a cross-over study, were treated with oral prednisolone (1 mg/kg 24 h) for 10 days. Blood samples were collected at day 0, 1, 3, 6, 9, 10, 12, 16, and 20. Data was analyzed using a general linear model with time and treatment as fixed factors. Pairwise comparisons were done between prednisolone and control period for each dog and sampling. Significant results were further evaluated for clinical relevance using laboratory-specific reference intervals and reference change values (RCVs), when available. Statistically significant changes were observed for ALP activity and iron concentration, which increased to levels exceeding the RCV, and several results were outside reference intervals. Phosphate and bile acids increased significantly, while amylase, lipase, and cholesterol decreased significantly, but with mean/median results remaining within reference intervals. Anti-inflammatory prednisolone treatment did not induce significant changes in ALT, GLDH, GGT, cPLI, glucose, or calcium. Treatment with an anti-inflammatory dose of prednisolone induced changes in several analytes. Only the increases in ALP and iron were of such magnitude that they are expected to affect the clinical interpretation of test results.

Authors/Creators:Pettersson, Helena and Ekstrand, Carl and Hillström, Anna and Lilliehöök, Inger
Title:Effect of 1 mg/kg oral prednisolone on biochemical analytes in ten dogs: a cross‑over study
Series Name/Journal:Comparative Clinical Pathology
Year of publishing :2021
Volume:30
Page range:519-528
Number of Pages:10
ISSN:1618-5641
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:Canine, Glucocorticoids, Biochemistry, Laboratory analysis
URN:NBN:urn:nbn:se:slu:epsilon-p-114630
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114630
Additional ID:
Type of IDID
DOI10.1007/s00580-021-03246-9
ID Code:26366
Faculty:University Animal Hospital
VH - Faculty of Veterinary Medicine and Animal Science
Department:University Animal Hospital (UAH)
(VH) > Dept. of Clinical Sciences
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:21 Dec 2021 14:25
Metadata Last Modified:21 Dec 2021 14:31

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