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Chlamydomonas proteases: classification, phylogeny, and molecular mechanisms

Zou, Yong and Bozhkov, Peter (2021). Chlamydomonas proteases: classification, phylogeny, and molecular mechanisms. Journal of Experimental Botany. 72 , 7680–7693
[Article Review/Survey]

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Abstract

Proteases can regulate myriad biochemical pathways by digesting or processing target proteins. While up to 3% of eukaryotic genes encode proteases, only a tiny fraction of proteases are mechanistically understood. Furthermore, most of the current knowledge about proteases is derived from studies of a few model organisms, including Arabidopsis thaliana in the case of plants. Proteases in other plant model systems are largely unexplored territory, limiting our mechanistic comprehension of post-translational regulation in plants and hampering integrated understanding of how proteolysis evolved. We argue that the unicellular green alga Chlamydomonas reinhardtii has a number of technical and biological advantages for systematic studies of proteases, including reduced complexity of many protease families and ease of cell phenotyping. With this end in view, we share a genome-wide inventory of proteolytic enzymes in Chlamydomonas, compare the protease degradomes of Chlamydomonas and Arabidopsis, and consider the phylogenetic relatedness of Chlamydomonas proteases to major taxonomic groups. Finally, we summarize the current knowledge of the biochemical regulation and physiological roles of proteases in this algal model. We anticipate that our survey will promote and streamline future research on Chlamydomonas proteases, generating new insights into proteolytic mechanisms and the evolution of digestive and limited proteolysis.

Authors/Creators:Zou, Yong and Bozhkov, Peter
Title:Chlamydomonas proteases: classification, phylogeny, and molecular mechanisms
Series Name/Journal:Journal of Experimental Botany
Year of publishing :2021
Volume:72
Page range:7680–7693
Number of Pages:14
ISSN:0022-0957
Language:English
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 404 Agricultural Biotechnology > Plant Biotechnology
Keywords:Arabidopsis, autophagy, Chlamydomonas, evolution, green algae, horizontal gene transfer, phylogeny, proteases, protein quality control, proteolytic substrates
URN:NBN:urn:nbn:se:slu:epsilon-p-114680
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114680
Additional ID:
Type of IDID
DOI10.1093/jxb/erab383
ID Code:26649
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:03 Jan 2022 08:25
Metadata Last Modified:03 Jan 2022 08:31

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