Hanås, Sofia
(2022).
Cardiac biomarkers in cats : associations with feline characteristics and hypertrophic cardiomyopathy.
Diss. (sammanfattning/summary)
Sveriges lantbruksuniv.,
Acta Universitatis Agriculturae Sueciae, 1652-6880
ISBN 978-91-7760-877-6
eISBN 978-91-7760-877-6
[Doctoral thesis]
![]() |
PDF
7MB |
Abstract
Cardiac biomarkers may be used to support diagnosis of diseases such as hypertrophic cardiomyopathy (HCM), a common cardiac disease in cats. However, the impact of feline characteristics on these biomarkers is relatively unexplored. The biomarkers N-terminal-prohormone-B-type natriuretic peptide (NTproBNP), cardiac troponin I (cTnI), microRNA (miRNA), blood pressure (BP) and pulse rate (PR) were studied in healthy Birman, Norwegian Forest (NF) and Domestic Shorthair (DSH) cats. Major aims of the thesis were to assess potential associations between these cardiac biomarkers and feline characteristics in healthy cats, and to compare measured values of the circulating biomarkers in healthy cats with cats with HCM. Blood pressure and PR increased with age, and NF and DSH cats had higher BP than Birman cats. For plasma NT‐proBNP, male cats had higher concentrations than female cats. Regarding cTnI, neutered male cats had higher serum concentrations than intact female cats, and Birman cats had higher cTnI concentrations than NF cats. In healthy cats, breed had an effect on miRNA-profiles in whole blood when NF cats were compared to DSH cats. In cats with HCM, NT-proBNP and cTnI concentrations were higher in cats with HCM and left atrial enlargement (LAE) than in cats with HCM without LAE and in healthy cats. In conclusion, in healthy cats, breed was associated with BP, cTnI and miRNA, sex was associated with NT-proBNP and cTnI, and age was associated with BP and PR. For NT-proBNP and cTnI, cats with HCM and LAE had higher concentrations than cats with HCM without LAE, and than in healthy cats.
Authors/Creators: | Hanås, Sofia |
---|---|
Title: | Cardiac biomarkers in cats : associations with feline characteristics and hypertrophic cardiomyopathy |
Series Name/Journal: | Acta Universitatis Agriculturae Sueciae |
Year of publishing : | 2022 |
Number: | 2022:1 |
Number of Pages: | 145 |
Publisher: | Swedish University of Agricultural Sciences |
ISBN for printed version: | 978-91-7760-877-6 |
ISBN for electronic version: | 978-91-7760-877-6 |
ISSN: | 1652-6880 |
Language: | English |
Publication Type: | Doctoral thesis |
Article category: | Other scientific |
Version: | Published version |
Copyright: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 |
Full Text Status: | Public |
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science |
Keywords: | troponin, blood pressure, NT-proBNP, miRNA, breed, Birman, Norwegian Forest, blodtryck, ras, Birma, norsk skogkatt |
URN:NBN: | urn:nbn:se:slu:epsilon-p-115083 |
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-115083 |
ID Code: | 26662 |
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science |
Department: | (VH) > Dept. of Clinical Sciences |
Deposited By: | SLUpub Connector |
Deposited On: | 05 Jan 2022 13:09 |
Metadata Last Modified: | 07 Jan 2022 15:00 |
Repository Staff Only: item control page