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Dissecting the genetics of athletic performance and conformation traits in horses

Rosengren, Maria (2022). Dissecting the genetics of athletic performance and conformation traits in horses. Diss. (sammanfattning/summary) Sveriges lantbruksuniv., Acta Universitatis Agriculturae Sueciae, 1652-6880
ISBN 978-91-7760-893-6
eISBN 978-91-7760-894-3
[Doctoral thesis]

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Abstract

The overall aims of this thesis were to investigate the genetics of athletic performance and the level of inbreeding in Coldblooded trotters, as well as the genetics of conformation traits in Icelandic horses. In paper I, genomic-based inbreeding coefficients in Coldblooded trotters were estimated and compared with pedigree-based coefficients. The results showed that the inbreeding level has gradually increased during the investigated years 2000-2009 and that genomic measures of inbreeding could be used to minimize further increased inbreeding. In papers II-IV, different genetic mapping methods were used to dissect the genetics of athletic performance in Coldblooded trotters. The results from papers II and III indicated that athletic performance requires not only physical characteristics but also mental qualities such as memory and learning. In paper IV, we investigated the genetics of athletic performance and exercise related blood pressure. An associated haplotype to these traits was identified. The relative quantitative proteomics analysis showed that proteins linked to inflammatory and coagulation processes were differentially expressed between the elite and sub-elite performing haplotype groups at rest and during exercise.
In paper V, we performed a genome-wide association study in Icelandic horses assessed at breeding field tests to dissect the genetics of conformation of back and croup. A quantitative trait locus for conformation of back and croup and quality of lateral gaits was identified. The genomic region harbored genes linked to anthropometric traits, scoliosis, and motor laterality in humans.
In conclusion, this thesis contributes to increased knowledge about the genetics of complex traits such as athletic performance, blood pressure regulation, inflammation, and anthropometric traits in horses. This information may also be of value for humans and other mammalian species.

Authors/Creators:Rosengren, Maria
Title:Dissecting the genetics of athletic performance and conformation traits in horses
Series Name/Journal:Acta Universitatis Agriculturae Sueciae
Year of publishing :2022
Number:2022:9
Number of Pages:87
Publisher:Swedish University of Agricultural Sciences
ISBN for printed version:978-91-7760-893-6
ISBN for electronic version:978-91-7760-894-3
ISSN:1652-6880
Language:English
Publication Type:Doctoral thesis
Article category:Other scientific
Version:Published version
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Genetics (medical genetics to be 30107 and agricultural genetics to be 40402)
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:Athletic performance, Blood pressure, Conformation, Equine, Inbreeding, Inflammation, Lateral gaits
URN:NBN:urn:nbn:se:slu:epsilon-p-115779
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-115779
ID Code:26827
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Animal Breeding and Genetics
Deposited By: SLUpub Connector
Deposited On:26 Jan 2022 10:25
Metadata Last Modified:26 Jan 2022 12:24

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