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Modeling metal oxide nanoparticle GABA interactions: Complexation between the Keggin POM and gamma-aminobutyric acid in the solid state and in solution influenced by additional ligands

Svensson, Fredric and Simon, Philipp and Kessler, Vadim (2021). Modeling metal oxide nanoparticle GABA interactions: Complexation between the Keggin POM and gamma-aminobutyric acid in the solid state and in solution influenced by additional ligands. Inorganica Chimica Acta. 526 , 120547
[Research article]

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Abstract

Phosphotungstic acid (POM) was crystallized together with the neurotransmitter gamma-aminobutyric acid (GABA) in acidic medium to form [(HGABA)3PW12O40], compound 1. The latter would only crystalize in the presence of dopamine, while dopamine itself did not become a part of the complex, but crystallized separately as [(Hdopamine)2HPW12O40], compound 2, as previously reported. GABA interacts with POM via hydrogen bonding between the protonated amino group and a terminal oxygen on POM and also via protonated carboxylic acid group. Based on structural information from the crystal structures of 1 and 2 together with complementary studies using other catechols we attempted to provide molecular insight into the well-known structure-directing effect of dopamine. Strong hydrogen bonding between dopamine and POM, together with formation of "dopamine dimers" in the packed structure by interactions between the aromatic rings and intermolecular hydrogen bonding might be important factors for them in directing the self-assembly of polyoxometalates into complex hierarchal structures. Interaction between dopamine and GABA in solution was investigated by diffusion ordered spectrometry (DOSY) NMR in MilliQ-water and in 0.1 M HCl.

Authors/Creators:Svensson, Fredric and Simon, Philipp and Kessler, Vadim
Title:Modeling metal oxide nanoparticle GABA interactions: Complexation between the Keggin POM and gamma-aminobutyric acid in the solid state and in solution influenced by additional ligands
Series Name/Journal:Inorganica Chimica Acta
Year of publishing :2021
Volume:526
Article number:120547
Number of Pages:6
Publisher:ELSEVIER SCIENCE SA
ISSN:0020-1693
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 104 Chemical Sciences > Inorganic Chemistry
Keywords:POM, Metal oxide nanoparticle, Biomarker complex, GABA, Dopamine, Structure-directing agent
URN:NBN:urn:nbn:se:slu:epsilon-p-113479
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-113479
Additional ID:
Type of IDID
DOI10.1016/j.ica.2021.120547
Web of Science (WoS)000687478500002
ID Code:27134
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:18 Feb 2022 09:25
Metadata Last Modified:18 Feb 2022 09:31

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