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Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP-B and SP-C

Basabe-Burgos, Oihana and Landreh, Michael and Rising, Anna and Curstedt, Tore and Johansson, Jan (2021). Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP-B and SP-C. ACS Chemical Biology. 16 :12 , 2864-2873
[Research article]

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Abstract

Treatment of respiratory distress syndrome (RDS) with surfactant replacement therapy in prematurely born infants was introduced more than 30 years ago; however, the surfactant preparations currently in clinical use are extracts from animal lungs. A synthetic surfactant that matches the currently used nature-derived surfactant preparations and can be produced in a cost-efficient manner would enable worldwide treatment of neonatal RDS and could also be tested against lung diseases in adults. The major challenge in developing fully functional synthetic surfactant preparations is to recapitulate the properties of the hydrophobic lung surfactant proteins B (SP-B) and SP-C. Here, we have designed single polypeptides that combine properties of SP-B and SP-C and produced them recombinantly using a novel solubility tag based on spider silk production. These Combo peptides mixed with phospholipids are as efficient as nature-derived surfactant preparations against neonatal RDS in premature rabbit fetuses.

Authors/Creators:Basabe-Burgos, Oihana and Landreh, Michael and Rising, Anna and Curstedt, Tore and Johansson, Jan
Title:Treatment of Respiratory Distress Syndrome with Single Recombinant Polypeptides that Combine Features of SP-B and SP-C
Series Name/Journal:ACS Chemical Biology
Year of publishing :2021
Volume:16
Number:12
Page range:2864-2873
Number of Pages:10
Publisher:AMER CHEMICAL SOC
ISSN:1554-8929
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Respiratory Medicine and Allergy
URN:NBN:urn:nbn:se:slu:epsilon-p-115155
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-115155
Additional ID:
Type of IDID
DOI10.1021/acschembio.1c00816
Web of Science (WoS)000730350300001
ID Code:27154
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:21 Feb 2022 11:25
Metadata Last Modified:21 Feb 2022 11:31

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