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Behavioral profiles of adolescent alcohol-preferring/non-preferring (P/NP) and high/low alcohol-drinking (HAD/LAD) rats are dependent on line but not sex

Lundberg, Stina and Roman, Erika and Bell, Richard L. (2022). Behavioral profiles of adolescent alcohol-preferring/non-preferring (P/NP) and high/low alcohol-drinking (HAD/LAD) rats are dependent on line but not sex. Frontiers in Neuroscience. 15 , 811401
[Research article]

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Abstract

Initial contact with alcohol generally occurs during adolescence, and high consumption during this period is associated with increased risk for later alcohol (AUDs) and/or substance use disorders (SUDs). Rodents selectively bred for high or low alcohol consumption are used to identify behavioral characteristics associated with a propensity for high or low voluntary alcohol intake. The multivariate concentric square field (TM) (MCSF) is a behavioral test developed to study rodents in a semi-naturalistic setting. Testing in the MCSF creates a comprehensive behavioral profile in a single trial. The current aim was to examine the behavioral profiles of adolescent, bidirectionally selectively bred male and female high alcohol-consuming (P and HAD1/2) and low alcohol-consuming (NP and LAD1/2) rat lines, and outbred Wistar rats. Alcohol-naive rats were tested once in the MCSF at an age between postnatal days 30 and 35. No common behavioral profile was found for either high or low alcohol-consuming rat lines, and the effect of sex was small. The P/NP and HAD2/LAD2 lines showed within pair-dependent differences, while the HAD1/LAD1 lines were highly similar. The P rats displayed high activity and risk-associated behaviors, whereas HAD2 rats displayed low activity, high shelter-seeking behavior, and open area avoidance. The results from P rats parallel clinical findings that denser family history and risk-taking behavior are strong predictors of future AUDs, often with early onset. Contrarily, the HAD2 behavioral profile was similar to individuals experiencing negative emotionality, which also is associated with a vulnerability to develop, often with a later onset, AUDs and/or SUDs.

Authors/Creators:Lundberg, Stina and Roman, Erika and Bell, Richard L.
Title:Behavioral profiles of adolescent alcohol-preferring/non-preferring (P/NP) and high/low alcohol-drinking (HAD/LAD) rats are dependent on line but not sex
Series Name/Journal:Frontiers in Neuroscience
Year of publishing :2022
Volume:15
Article number:811401
Number of Pages:15
ISSN:1662-4548
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Neurosciences
Keywords:adolescence, alcohol non-preferring rats, alcohol-preferring rats, high alcohol-drinking rats, low alcohol-drinking rats, multivariate concentric square field (MCSF)
URN:NBN:urn:nbn:se:slu:epsilon-p-115513
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-115513
Additional ID:
Type of IDID
DOI10.3389/fnins.2021.811401
Web of Science (WoS)000749880700001
ID Code:27189
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:23 Feb 2022 14:25
Metadata Last Modified:23 Feb 2022 14:31

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