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Investigation of extramammary sources of Group B Streptococcus reveals its unusual ecology and epidemiology in camels

Seligsohn, Dinah and Crestani, Chiara and Gitahi, Nduhiu and Lejon Flodin, Emelie and Chenais, Erika and Zadoks, Ruth N. (2021). Investigation of extramammary sources of Group B Streptococcus reveals its unusual ecology and epidemiology in camels. PLoS ONE. 16 :12 , e0252973
[Research article]

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Abstract

Camels are vital to food production in the drylands of the Horn of Africa, with milk as their main contribution to food security. A major constraint to camel milk production is mastitis, inflammation of the mammary gland. The condition negatively impacts milk yield and quality as well as household income. A leading cause of mastitis in dairy camels is Streptococcus agalactiae, or group B Streptococcus (GBS), which is also a commensal and pathogen of humans and cattle. It has been suggested that extramammary reservoirs for this pathogen may contribute to the occurrence of mastitis in camels. We explored the molecular epidemiology of GBS in camels using a cross-sectional study design for sample collection and phenotypic, genomic and phylogenetic analysis of isolates. Among 88 adult camels and 93 calves from six herds in Laikipia County, Kenya, GBS was detected in 20% of 50 milk samples, 25% of 152 nasal swabs, 8% of 90 oral swabs and 3% of 90 rectal swabs, but not in vaginal swabs. Per camel herd, two to four sequence types (ST) were identified using Multi Locus Sequence Typing (MLST). More than half of the isolates belonged to ST617 or its single-locus variant, ST1652, with these STs found across all sample types. Capsular serotype VI was detected in 30 of 58 isolates. In three herds, identical STs were detected in milk and swab samples, suggesting that extramammary sources of GBS may contribute to the maintenance and spread of GBS within camel herds. This needs to be considered when developing prevention and control strategies for GBS mastitis. The high nasal carriage rate, low recto-vaginal carriage rate, and high prevalence of serotype VI for GBS in camels are in stark contrast to the distribution of GBS in humans and in cattle and reveal hitherto unknown ecological and molecular features of this bacterial species.

Authors/Creators:Seligsohn, Dinah and Crestani, Chiara and Gitahi, Nduhiu and Lejon Flodin, Emelie and Chenais, Erika and Zadoks, Ruth N.
Title:Investigation of extramammary sources of Group B Streptococcus reveals its unusual ecology and epidemiology in camels
Series Name/Journal:PLoS ONE
Year of publishing :2021
Volume:16
Number:12
Article number:e0252973
Number of Pages:18
Publisher:PUBLIC LIBRARY SCIENCE
ISSN:1932-6203
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
URN:NBN:urn:nbn:se:slu:epsilon-p-116209
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-116209
Additional ID:
Type of IDID
DOI10.1371/journal.pone.0252973
Web of Science (WoS)000754686900001
ID Code:27203
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:25 Feb 2022 06:25
Metadata Last Modified:07 Oct 2022 02:31

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