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Tetramic acid based alkaloids from Aspergillus amoenus Roberg strain UP197-antibiotic properties and new pyranterreones

Nord, Christina and Levenfors, Jolanta and Bjerketorp, Joakim and Guss, Bengt and Öberg, Bo and Broberg, Henrik (2022). Tetramic acid based alkaloids from Aspergillus amoenus Roberg strain UP197-antibiotic properties and new pyranterreones. Natural Product Research. 36 :4 , 967-973
[Research article]

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Abstract

The fungus Aspergillus amoenus Roberg strain UP197 was shown to produce antibacterial tetramic acid based alkaloids. Two new compounds, pyranterreone I and J (1 and 2), were isolated and characterized, in addition to the known compounds cordylactam, 7-hydroxycordylactam, pyranterreone C, D, F and G. Neither the pyranterreones nor the cordylacctams had previously been tested for antimicrobial activity. Thus, all isolated compounds were tested against a panel of clinically important bacteria and fungi. Pyranterreone C was active against Gram-positive and Gram-negative bacteria, with minimal inhibitory concentrations (MIC) between 1 and 8 mu g/mL, whereas the MICs for all other compounds were >32 mu g/mL. Pyranoterreone C was cytotoxic towards HepG2 cells, and since pyranterreone C reacted rapidly with the nucleophile cysteine, it is likely that the observed antibacterial activity is due to the chemical reactivity rather than enzymatic affinity, making it unsuitable for development as an antibacterial drug.

Authors/Creators:Nord, Christina and Levenfors, Jolanta and Bjerketorp, Joakim and Guss, Bengt and Öberg, Bo and Broberg, Henrik
Title:Tetramic acid based alkaloids from Aspergillus amoenus Roberg strain UP197-antibiotic properties and new pyranterreones
Series Name/Journal:Natural Product Research
Year of publishing :2022
Volume:36
Number:4
Page range:967-973
Number of Pages:7
Publisher:TAYLOR AND FRANCIS LTD
ISSN:1478-6419
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Medicinal Chemistry
Keywords:Aspergillus amoenus, alkaloids, pyranterreone, antibacterial, cytotoxic
URN:NBN:urn:nbn:se:slu:epsilon-p-110481
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-110481
Additional ID:
Type of IDID
DOI10.1080/14786419.2020.1855643
Web of Science (WoS)000596160400001
ID Code:27255
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
VH - Faculty of Veterinary Medicine and Animal Science
Department:(NL, NJ) > Department of Molecular Sciences
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:04 Mar 2022 15:35
Metadata Last Modified:13 Jun 2022 10:27

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