Dahlin, Joakim S. and Maurer, Marcus and Metcalfe, Dean D. and Pejler, Gunnar and Sagi-Eisenberg, Ronit and Nilsson, Gunnar
(2022).
The ingenious mast cell: Contemporary insights into mast cell behavior and function.
Allergy. 77
:1
, 83-99
[Research article]
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Abstract
Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non-immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. During recent years, clinical and experimental studies on human mast cells, as well as experiments using animal models, have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review, we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity, and reactivity. We also highlight the development in our understanding of mast cell-driven diseases and discuss the development of novel strategies to treat such conditions.
| Authors/Creators: | Dahlin, Joakim S. and Maurer, Marcus and Metcalfe, Dean D. and Pejler, Gunnar and Sagi-Eisenberg, Ronit and Nilsson, Gunnar | ||||||
|---|---|---|---|---|---|---|---|
| Title: | The ingenious mast cell: Contemporary insights into mast cell behavior and function | ||||||
| Series Name/Journal: | Allergy | ||||||
| Year of publishing : | 2022 | ||||||
| Volume: | 77 | ||||||
| Number: | 1 | ||||||
| Page range: | 83-99 | ||||||
| Number of Pages: | 17 | ||||||
| Publisher: | WILEY | ||||||
| ISSN: | 0105-4538 | ||||||
| Language: | English | ||||||
| Publication Type: | Research article | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Immunology in the medical area | ||||||
| Keywords: | allergy, anaphylaxis, animal models, asthma, inflammation, Mast cells, mastocytosis, urticaria | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-p-112003 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112003 | ||||||
| Additional ID: |
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| ID Code: | 27303 | ||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
| Department: | (VH) > Dept. of Anatomy, Physiology and Biochemistry | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 14 Mar 2022 10:25 | ||||||
| Metadata Last Modified: | 14 Mar 2022 10:31 |
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