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The ingenious mast cell: Contemporary insights into mast cell behavior and function

Dahlin, Joakim S. and Maurer, Marcus and Metcalfe, Dean D. and Pejler, Gunnar and Sagi-Eisenberg, Ronit and Nilsson, Gunnar (2022). The ingenious mast cell: Contemporary insights into mast cell behavior and function. Allergy. 77 :1 , 83-99
[Research article]

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Abstract

Mast cells are (in)famous for their role in allergic diseases, but the physiological and pathophysiological roles of this ingenious cell are still not fully understood. Mast cells are important for homeostasis and surveillance of the human system, recognizing both endogenous and exogenous agents, which induce release of a variety of mediators acting on both immune and non-immune cells, including nerve cells, fibroblasts, endothelial cells, smooth muscle cells, and epithelial cells. During recent years, clinical and experimental studies on human mast cells, as well as experiments using animal models, have resulted in many discoveries that help decipher the function of mast cells in health and disease. In this review, we focus particularly on new insights into mast cell biology, with a focus on mast cell development, recruitment, heterogeneity, and reactivity. We also highlight the development in our understanding of mast cell-driven diseases and discuss the development of novel strategies to treat such conditions.

Authors/Creators:Dahlin, Joakim S. and Maurer, Marcus and Metcalfe, Dean D. and Pejler, Gunnar and Sagi-Eisenberg, Ronit and Nilsson, Gunnar
Title:The ingenious mast cell: Contemporary insights into mast cell behavior and function
Series Name/Journal:Allergy
Year of publishing :2022
Volume:77
Number:1
Page range:83-99
Number of Pages:17
Publisher:WILEY
ISSN:0105-4538
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Immunology in the medical area
Keywords:allergy, anaphylaxis, animal models, asthma, inflammation, Mast cells, mastocytosis, urticaria
URN:NBN:urn:nbn:se:slu:epsilon-p-112003
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-112003
Additional ID:
Type of IDID
DOI10.1111/all.14881
Web of Science (WoS)000652196800001
ID Code:27303
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:14 Mar 2022 10:25
Metadata Last Modified:14 Mar 2022 10:31

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