Rhodin, Marie and Haubro Andersen, Pia and Holm Forsström, Karin and Ekstrand, Carl
(2022).
In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses.
Journal of Veterinary Pharmacology and Therapeutics. 45
:2
, 167-176
[Research article]
![]() |
PDF
725kB |
Abstract
Intra-articular administration of sustained-release anti-inflammatory drugs is indicated in horses suffering from joint inflammation, but no such drugs are labelled for veterinary use. To obtain initial data on synovial disposition and safety of a new sustained-release formulation of diclofenac (SYN321) in the joints of horses, an experimental interventional study of elimination and side effects of intra-articular administration of SYN321 was conducted. Nine clinically sound horses were included in the study, and SYN321 was administered by the intra-articular route. Dose ranges and sampling intervals were established in a pilot study with two horses, and then applied in a main study involving seven horses treated in the fetlock joint. Diclofenac was detected above lower limit of quantification (LOQ: 0.5 ng/ml) in synovial fluid throughout the study period (14 days), and below LOQ (0.1 ng/ml) in plasma after 4 days and in urine after 14 days. No obvious clinical side effects were detected. Clinical examination and objective lameness evaluation suggested that SYN321 has potential as a local joint NSAID treatment with sustained release in horses, but further studies on synovial fluid exposure, safety and clinical efficacy are warranted.
Authors/Creators: | Rhodin, Marie and Haubro Andersen, Pia and Holm Forsström, Karin and Ekstrand, Carl | ||||||
---|---|---|---|---|---|---|---|
Title: | In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses | ||||||
Series Name/Journal: | Journal of Veterinary Pharmacology and Therapeutics | ||||||
Year of publishing : | 2022 | ||||||
Volume: | 45 | ||||||
Number: | 2 | ||||||
Page range: | 167-176 | ||||||
Number of Pages: | 10 | ||||||
Publisher: | WILEY | ||||||
ISSN: | 0140-7783 | ||||||
Language: | English | ||||||
Publication Type: | Research article | ||||||
Article category: | Scientific peer reviewed | ||||||
Version: | Published version | ||||||
Copyright: | Creative Commons: Attribution-Noncommercial 4.0 | ||||||
Full Text Status: | Public | ||||||
Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||
Keywords: | equine, intra-articular, NSAID, pharmacokinetics, slow-release | ||||||
URN:NBN: | urn:nbn:se:slu:epsilon-p-114913 | ||||||
Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114913 | ||||||
Additional ID: |
| ||||||
ID Code: | 27304 | ||||||
Faculty: | VH - Faculty of Veterinary Medicine and Animal Science University Animal Hospital | ||||||
Department: | (VH) > Dept. of Anatomy, Physiology and Biochemistry University Animal Hospital (UAH) (VH) > Department of Biomedical Science and Veterinary Public Health | ||||||
Deposited By: | SLUpub Connector | ||||||
Deposited On: | 14 Mar 2022 10:25 | ||||||
Metadata Last Modified: | 14 Mar 2022 10:31 |
Repository Staff Only: item control page