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In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses

Rhodin, Marie and Haubro Andersen, Pia and Holm Forsström, Karin and Ekstrand, Carl (2022). In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses. Journal of Veterinary Pharmacology and Therapeutics. 45 :2 , 167-176
[Research article]

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Abstract

Intra-articular administration of sustained-release anti-inflammatory drugs is indicated in horses suffering from joint inflammation, but no such drugs are labelled for veterinary use. To obtain initial data on synovial disposition and safety of a new sustained-release formulation of diclofenac (SYN321) in the joints of horses, an experimental interventional study of elimination and side effects of intra-articular administration of SYN321 was conducted. Nine clinically sound horses were included in the study, and SYN321 was administered by the intra-articular route. Dose ranges and sampling intervals were established in a pilot study with two horses, and then applied in a main study involving seven horses treated in the fetlock joint. Diclofenac was detected above lower limit of quantification (LOQ: 0.5 ng/ml) in synovial fluid throughout the study period (14 days), and below LOQ (0.1 ng/ml) in plasma after 4 days and in urine after 14 days. No obvious clinical side effects were detected. Clinical examination and objective lameness evaluation suggested that SYN321 has potential as a local joint NSAID treatment with sustained release in horses, but further studies on synovial fluid exposure, safety and clinical efficacy are warranted.

Authors/Creators:Rhodin, Marie and Haubro Andersen, Pia and Holm Forsström, Karin and Ekstrand, Carl
Title:In vivo joint synovial fluid disposition of a novel sustained-release formulation of diclofenac and hyaluronic acid in horses
Series Name/Journal:Journal of Veterinary Pharmacology and Therapeutics
Year of publishing :2022
Volume:45
Number:2
Page range:167-176
Number of Pages:10
Publisher:WILEY
ISSN:0140-7783
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
Keywords:equine, intra-articular, NSAID, pharmacokinetics, slow-release
URN:NBN:urn:nbn:se:slu:epsilon-p-114913
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114913
Additional ID:
Type of IDID
DOI10.1111/jvp.13033
Web of Science (WoS)000726318500001
ID Code:27304
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
University Animal Hospital
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
University Animal Hospital (UAH)
(VH) > Department of Biomedical Science and Veterinary Public Health
Deposited By: SLUpub Connector
Deposited On:14 Mar 2022 10:25
Metadata Last Modified:14 Mar 2022 10:31

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