Larsen, Jesper and Raisen, Claire L. and Ba, Xiaoliang and Sadgrove, Nicholas J. and Padilla-Gonzalez, Guillermo F. and Simmonds, Monique S. J. and Loncaric, Igor and Deplano, Ariane and Vandendriessche, Stien and Bolfikova, Barbora Cerna and Hulva, Pavel and Arendrup, Maiken C. and Hare, Rasmus K. and Barnadas, Celine and Stegger, Marc and Sieber, Raphael N. and Skov, Robert L. and Petersen, Andreas and Angen, Oystein and Rasmussen, Sophie L. and Espinosa-Gongora, Carmen and Aarestrup, Frank M. and Lindholm, Laura J. and Nykasenoja, Suvi M. and Becker, Karsten and Walther, Birgit and Kehrenberg, Corinna and Cuny, Christiane and Layer, Franziska and Werner, Guido and Witte, Wolfgang and Moroni, Paolo and Jorgensen, Hannah J. and de Lencastre, Herminia and Cercenado, Emilia and Garcia-Garrote, Fernando and Borjesson, Stefan and Haeggman, Sara and Perreten, Vincent and Waller, Andrew and Curran, Martin D. and Ellington, Matthew J. and Welch, John J. and Peacock, Sharon J. and Seilly, David J. and Morgan, Fiona J. E. and Parkhill, Julian and Hadjirin, Nazreen F. and Lindsay, Jodi A. and Holden, Matthew T. G. and Paterson, Gavin K. and Didelot, Xavier and Holmes, Mark A. and Harrison, Ewan M. and Larsen, Anders R.
(2022).
Emergence of methicillin resistance predates the clinical use of antibiotics.
Nature. 602
:7895
, 135-141
[Research article]
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Abstract
The discovery of antibiotics more than 80 years ago has led to considerable improvements in human and animal health. Although antibiotic resistance in environmental bacteria is ancient, resistance in human pathogens is thought to be a modern phenomenon that is driven by the clinical use of antibiotics(1). Here we show that particular lineages of methicillin-resistant Staphylococcus aureus-a notorious human pathogen-appeared in European hedgehogs in the pre-antibiotic era. Subsequently, these lineages spread within the local hedgehog populations and between hedgehogs and secondary hosts, including livestock and humans. We also demonstrate that the hedgehog dermatophyte Trichophyton erinacei produces two beta-lactam antibiotics that provide a natural selective environment in which methicillin-resistant S. aureus isolates have an advantage over susceptible isolates. Together, these results suggest that methicillin resistance emerged in the pre-antibiotic era as a co-evolutionary adaptation of S. aureus to the colonization of dermatophyte-infected hedgehogs. The evolution of clinically relevant antibiotic-resistance genes in wild animals and the connectivity of natural, agricultural and human ecosystems demonstrate that the use of a One Health approach is critical for our understanding and management of antibiotic resistance, which is one of the biggest threats to global health, food security and development.
| Authors/Creators: | Larsen, Jesper and Raisen, Claire L. and Ba, Xiaoliang and Sadgrove, Nicholas J. and Padilla-Gonzalez, Guillermo F. and Simmonds, Monique S. J. and Loncaric, Igor and Deplano, Ariane and Vandendriessche, Stien and Bolfikova, Barbora Cerna and Hulva, Pavel and Arendrup, Maiken C. and Hare, Rasmus K. and Barnadas, Celine and Stegger, Marc and Sieber, Raphael N. and Skov, Robert L. and Petersen, Andreas and Angen, Oystein and Rasmussen, Sophie L. and Espinosa-Gongora, Carmen and Aarestrup, Frank M. and Lindholm, Laura J. and Nykasenoja, Suvi M. and Becker, Karsten and Walther, Birgit and Kehrenberg, Corinna and Cuny, Christiane and Layer, Franziska and Werner, Guido and Witte, Wolfgang and Moroni, Paolo and Jorgensen, Hannah J. and de Lencastre, Herminia and Cercenado, Emilia and Garcia-Garrote, Fernando and Borjesson, Stefan and Haeggman, Sara and Perreten, Vincent and Waller, Andrew and Curran, Martin D. and Ellington, Matthew J. and Welch, John J. and Peacock, Sharon J. and Seilly, David J. and Morgan, Fiona J. E. and Parkhill, Julian and Hadjirin, Nazreen F. and Lindsay, Jodi A. and Holden, Matthew T. G. and Paterson, Gavin K. and Didelot, Xavier and Holmes, Mark A. and Harrison, Ewan M. and Larsen, Anders R. | ||||||
|---|---|---|---|---|---|---|---|
| Title: | Emergence of methicillin resistance predates the clinical use of antibiotics | ||||||
| Series Name/Journal: | Nature | ||||||
| Year of publishing : | 2022 | ||||||
| Volume: | 602 | ||||||
| Number: | 7895 | ||||||
| Page range: | 135-141 | ||||||
| Number of Pages: | 7 | ||||||
| Publisher: | NATURE PORTFOLIO | ||||||
| ISSN: | 0028-0836 | ||||||
| Language: | English | ||||||
| Publication Type: | Research article | ||||||
| Article category: | Scientific peer reviewed | ||||||
| Version: | Published version | ||||||
| Copyright: | Creative Commons: Attribution 4.0 | ||||||
| Full Text Status: | Public | ||||||
| Subjects: | (A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science | ||||||
| URN:NBN: | urn:nbn:se:slu:epsilon-p-115381 | ||||||
| Permanent URL: | http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-115381 | ||||||
| Additional ID: |
| ||||||
| ID Code: | 27464 | ||||||
| Faculty: | VH - Faculty of Veterinary Medicine and Animal Science | ||||||
| Department: | (VH) > Department of Biomedical Science and Veterinary Public Health | ||||||
| Deposited By: | SLUpub Connector | ||||||
| Deposited On: | 28 Mar 2022 14:28 | ||||||
| Metadata Last Modified: | 28 Mar 2022 14:31 |
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