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Functional connectivity in reward-related networks is associated with individual differences in gambling strategies in male Lister Hooded rats

Tjernström, Nikita and Li, Tie-Qiang and Holst, Sarah and Roman, Erika (2022). Functional connectivity in reward-related networks is associated with individual differences in gambling strategies in male Lister Hooded rats. Addiction Biology. 27 :2 , e13131
[Research article]

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Abstract

Individuals with gambling disorder display deficits in decision-making in the Iowa Gambling Task. The rat Gambling Task (rGT) is a rodent analogue that can be used to investigate the neurobiological mechanisms underlying gambling behaviour. The aim of this explorative study was to examine individual strategies in the rGT and investigate possible behavioural and neural correlates associated with gambling strategies. Thirty-two adult male Lister hooded rats underwent behavioural testing in the multivariate concentric square field™ (MCSF) and the novel cage tests, were trained on and performed the rGT and subsequently underwent resting-state functional magnetic resonance imaging (R-fMRI). In the rGT, stable gambling strategies were found with subgroups of rats that preferred the suboptimal safest choice as well as the disadvantageous choice, that is, the riskiest gambling strategy. R-fMRI results revealed associations between gambling strategies and brain regions central for reward networks. Moreover, rats with risky gambling strategies differed from those with strategic and intermediate strategies in brain functional connectivity. No differences in behavioural profiles, as assessed with the MCSF and novel cage tests, were observed between the gambling strategy groups. In conclusion, stable individual differences in gambling strategies were found. Intrinsic functional connectivity using R-fMRI provides novel evidence to support the notion that individual differences in gambling strategies are associated with functional connectivity in brain regions important for reward networks.

Authors/Creators:Tjernström, Nikita and Li, Tie-Qiang and Holst, Sarah and Roman, Erika
Title:Functional connectivity in reward-related networks is associated with individual differences in gambling strategies in male Lister Hooded rats
Series Name/Journal:Addiction Biology
Year of publishing :2022
Volume:27
Number:2
Article number:e13131
Number of Pages:16
ISSN:1355-6215
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial-No Derivative Works 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 301 Basic Medicine > Neurosciences
Keywords:behaviour, functional connectivity metrics, multivariate concentric square field, novel cage, ratgambling task, resting-state fMRIA
URN:NBN:urn:nbn:se:slu:epsilon-p-115514
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-115514
Additional ID:
Type of IDID
DOI10.1111/adb.13131
ID Code:27476
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Anatomy, Physiology and Biochemistry
Deposited By: SLUpub Connector
Deposited On:29 Mar 2022 14:25
Metadata Last Modified:29 Mar 2022 14:31

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