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Demographic History and Natural Selection Shape Patterns of Deleterious Mutation Load and Barriers to Introgression across Populus Genome

Liu, Shuyu and Zhang, Lei and Sang, Yupeng and Lai, Qiang and Zhang, Xinxin and Jia, Changfu and Long, Zhiqin and Wu, Jiali and Ma, Tao and Mao, Kangshan and Street, Nathaniel R. and Ingvarsson, Pär and Liu, Jianquan and Wang, Jing (2022). Demographic History and Natural Selection Shape Patterns of Deleterious Mutation Load and Barriers to Introgression across Populus Genome. Molecular Biology and Evolution. 39 :2 , msac008
[Research article]

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Abstract

Hybridization and resulting introgression are important processes shaping the tree of life and appear to be far more common than previously thought. However, how the genome evolution was shaped by various genetic and evolutionary forces after hybridization remains unresolved. Here we used whole-genome resequencing data of 227 individuals from multiple widespread Populus species to characterize their contemporary patterns of hybridization and to quantify genomic signatures of past introgression. We observe a high frequency of contemporary hybridization and confirm that multiple previously ambiguous species are in fact F-1 hybrids. Seven species were identified, which experienced different demographic histories that resulted in strikingly varied efficacy of selection and burdens of deleterious mutations. Frequent past introgression has been found to be a pervasive feature throughout the speciation of these Populus species. The retained introgressed regions, more generally, tend to contain reduced genetic load and to be located in regions of high recombination. We also find that in pairs of species with substantial differences in effective population size, introgressed regions are inferred to have undergone selective sweeps at greater than expected frequencies in the species with lower effective population size, suggesting that introgression likely have higher potential to provide beneficial variation for species with small populations. Our results, therefore, illustrate that demography and recombination have interplayed with both positive and negative selection in determining the genomic evolution after hybridization.

Authors/Creators:Liu, Shuyu and Zhang, Lei and Sang, Yupeng and Lai, Qiang and Zhang, Xinxin and Jia, Changfu and Long, Zhiqin and Wu, Jiali and Ma, Tao and Mao, Kangshan and Street, Nathaniel R. and Ingvarsson, Pär and Liu, Jianquan and Wang, Jing
Title:Demographic History and Natural Selection Shape Patterns of Deleterious Mutation Load and Barriers to Introgression across Populus Genome
Series Name/Journal:Molecular Biology and Evolution
Year of publishing :2022
Volume:39
Number:2
Article number:msac008
Number of Pages:16
Publisher:OXFORD UNIV PRESS
ISSN:0737-4038
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution-Noncommercial 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 1 Natural sciences > 106 Biological Sciences (Medical to be 3 and Agricultural to be 4) > Evolutionary Biology
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 401 Agricultural, Forestry and Fisheries > Agricultural Science
Keywords:hybridization, genetic load, natural selection, adaptive introgression, Populus
URN:NBN:urn:nbn:se:slu:epsilon-p-116683
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-116683
Additional ID:
Type of IDID
DOI10.1093/molbev/msac008
Web of Science (WoS)000767848900013
ID Code:27640
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Dept. of Plant Biology and Forest Genetics (until 131231)
Deposited By: SLUpub Connector
Deposited On:26 Apr 2022 15:25
Metadata Last Modified:26 Apr 2022 15:31

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