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An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method

Nordin, Elise and Steffensen, Stine K. and Laursen, Bente B. and Andersson, Sven-Olof and Johansson, Jan-Erik and Åman, Per and Hallmans, Goran and Borre, Michael and Staerk, Dan and Hanhineva, Kati and Fomsgaard, Inge S. and Landberg, Rikard (2022). An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method. Scientific Reports. 12 , 5260
[Research article]

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Abstract

Prostate cancer (PC) is a common cancer among men, and preventive strategies are warranted. Benzoxazinoids (BXs) in rye have shown potential against PC in vitro but human studies are lacking. The aim was to establish a quantitative method for analysis of BXs and investigate their plasma levels after a whole grain/bran rye vs refined wheat intervention, as well as exploring their association with PSA, in men with PC. A quantitative method for analysis of 22 BXs, including novel metabolites identified by mass spectrometry and NMR, was established, and applied to plasma samples from a randomized crossover study where patients with indolent PC (n = 17) consumed 485 g whole grain rye/rye bran or fiber supplemented refined wheat daily for 6 wk. Most BXs were significantly higher in plasma after rye (0.3-19.4 nmol/L in plasma) vs. refined wheat (0.05-2.9 nmol/L) intake. HBOA-glc, 2-HHPAA, HBOA-glcA, 2-HPAA-glcA were inversely correlated to PSA in plasma (p < 0.04). To conclude, BXs in plasma, including metabolites not previously analyzed, were quantified. BX metabolites were significantly higher after rye vs refined wheat consumption. Four BX-related metabolites were inversely associated with PSA, which merits further investigation.

Authors/Creators:Nordin, Elise and Steffensen, Stine K. and Laursen, Bente B. and Andersson, Sven-Olof and Johansson, Jan-Erik and Åman, Per and Hallmans, Goran and Borre, Michael and Staerk, Dan and Hanhineva, Kati and Fomsgaard, Inge S. and Landberg, Rikard
Title:An inverse association between plasma benzoxazinoid metabolites and PSA after rye intake in men with prostate cancer revealed with a new method
Series Name/Journal:Scientific Reports
Year of publishing :2022
Volume:12
Article number:5260
Number of Pages:14
Publisher:NATURE PORTFOLIO
ISSN:2045-2322
Language:English
Publication Type:Research article
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 303 Health Sciences > Nutrition and Dietetics
(A) Swedish standard research categories 2011 > 3 Medical and Health Sciences > 302 Clinical Medicine > Clinical Laboratory Medicine
URN:NBN:urn:nbn:se:slu:epsilon-p-116837
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-116837
Additional ID:
Type of IDID
DOI10.1038/s41598-022-08856-z
Web of Science (WoS)000774204500041
ID Code:27686
Faculty:NJ - Fakulteten för naturresurser och jordbruksvetenskap
Department:(NL, NJ) > Department of Molecular Sciences
Deposited By: SLUpub Connector
Deposited On:02 May 2022 14:42
Metadata Last Modified:02 May 2022 14:51

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