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A novel approach to minimising acute equine endometritis that may help to prevent the development of the chronic state

Morrell, Jane and Rocha, Antonio M. (2022). A novel approach to minimising acute equine endometritis that may help to prevent the development of the chronic state. Frontiers in Veterinary Science. 8 , 799619
[Article Review/Survey]

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Abstract

One of the most commonly encountered challenges in equine breeding is endometritis, which can be difficult to resolve and causes considerable economic losses to the industry. It is a multifactorial condition, developing as an exaggerated form of the normal physiological response to breeding. Seminal plasma proteins, spermatozoa, bacteria and debris initiate an inflammatory response; the resulting fluid and neutrophils are then cleared from the uterus along with the debris. However, in some mares, the response is prolonged or exaggerated, with much fluid formation and neutrophil infiltration leading to acute endometritis. A bacterial cause has been implicated, although in some cases no pathogenic organisms can be isolated on culture. It has been postulated that any one of a variety of bacteria could be involved, or dysbiosis of the uterine microbiome could be responsible. Repeated episodes of acute endometritis may lead to the pathology associated with chronic endometritis, with mucociliary dysfunction, vascular degeneration and plasma cell infiltration. This review examines the information that is currently available about equine endometritis, particularly about the role of the inseminate in the uterus, and its current treatment. There are some promising lines of research into treatment or prevention that may help to resolve the issue.

Authors/Creators:Morrell, Jane and Rocha, Antonio M.
Title:A novel approach to minimising acute equine endometritis that may help to prevent the development of the chronic state
Series Name/Journal:Frontiers in Veterinary Science
Year of publishing :2022
Volume:8
Article number:799619
Number of Pages:11
ISSN:2297-1769
Language:English
Publication Type:Article Review/Survey
Article category:Scientific peer reviewed
Version:Published version
Copyright:Creative Commons: Attribution 4.0
Full Text Status:Public
Subjects:(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 403 Veterinary Science > Clinical Science
(A) Swedish standard research categories 2011 > 4 Agricultural Sciences > 402 Animal and Dairy Science > Animal and Dairy Science.
Keywords:Post-breeding endometritis, Acute endometritis, fluid and leucocyte accumulation, Bacteria, altered mucociliary activity, Plasma cell infiltration, chronic endometritis.
URN:NBN:urn:nbn:se:slu:epsilon-p-114575
Permanent URL:
http://urn.kb.se/resolve?urn=urn:nbn:se:slu:epsilon-p-114575
Additional ID:
Type of IDID
DOI10.3389/fvets.2021.799619
Web of Science (WoS)000745182800001
ID Code:27693
Faculty:VH - Faculty of Veterinary Medicine and Animal Science
Department:(VH) > Dept. of Clinical Sciences
Deposited By: SLUpub Connector
Deposited On:03 May 2022 13:25
Metadata Last Modified:03 May 2022 13:31

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